Results 61 to 70 of about 601,576 (268)

Recent Progress in Hydrogen Flammability Prediction for the Safe Energy Systems

Energies, 2020
Many countries consider hydrogen as a promising energy source to resolve the energy challenges over the global climate change. However, the potential of hydrogen explosions remains a technical issue to embrace hydrogen as an alternate solution since the ...
Joongoo Jeon, Sung Joong Kim
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Development of On-Board In-Cylinder Gas Flow Model for Heat Loss Estimation of Diesel Engines

JIRAE (International Journal of Industrial Research and Applied Engineering), 2018
Diesel engines have been demanded to further increase the thermal efficiency through precise engine control under transient driving conditions, especially, it is essential to optimize the fuel injection timing and quantity cycle-by-cycle. Conventionally,
Mitsuhisa Ichiyanagi, Kazuki Kojima, Hayao Joji, Hiroki Matsui, Takashi Suzuki   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Development of On-board Polytropic Index Prediction Model for Injection Timing Optimization of Diesel Engines

JIRAE (International Journal of Industrial Research and Applied Engineering), 2018
Diesel engines are required to reduce exhaust emissions during real-world operations. In this regard, a new control concept called model-based control has been explored.
Mitsuhisa Ichiyanagi, Hayao Joji, Hiroki Matsui, Emir Yilmaz, Takashi Suzuki   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mathematical Modeling of Heat Transfer and Energy Efficiency in Above-Ground Outdoor Pools

AppliedMath
Above-ground outdoor swimming pools are increasingly popular due to their affordability and ease of installation, yet maintaining optimal water temperature under variable climate conditions remains challenging.
Łukasz Dziubiński, Paweł Chwietczuk, Seweryn Lipiński   +2 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Heat Transfer Modeling of Hydrogen-Fueled Spark Ignition Engine

Energies
Currently, green hydrogen, generated through renewable energy sources, stands out as one of the best substitutes for fossil fuels in mitigating pollutant emissions and consequent global warming. Particularly, the utilization of hydrogen in spark ignition
Stefano Beccari, Emiliano Pipitone
doaj   +1 more source