Results 1 to 10 of about 117,106 (293)

Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis. [PDF]

Cell Rep, 2018
The effector B cell lymphoma-2 (BCL-2) protein BCL-2 ovarian killer (BOK) induces mitochondrial outer membrane permeabilization (MOMP) to initiate apoptosis upon inhibition of the proteasome. How BOK mediates MOMP is mechanistically unknown. The NMR structure of the BCL-2 core of human BOK reveals a conserved architecture with an atypical hydrophobic ...
Zheng JH, Grace CR, Guibao CD, McNamara DE, Llambi F, Wang YM, Chen T, Moldoveanu T.   +7 more
europepmc   +3 more sources

Chromosomal Instability Confers Intrinsic Multidrug Resistance [PDF]

Cancer Research, 2011
Abstract Aneuploidy is associated with poor prognosis in solid tumors. Spontaneous chromosome missegregation events in aneuploid cells promote chromosomal instability (CIN) that may contribute to the acquisition of multidrug resistance in vitro and heighten risk for tumor relapse in animal models.
Alvin J X, Lee, David, Endesfelder, Andrew J, Rowan, Axel, Walther, Nicolai J, Birkbak, P Andrew, Futreal, Julian, Downward, Zoltan, Szallasi, Ian P M, Tomlinson, Michael, Howell, Maik, Kschischo, Charles, Swanton   +11 more
openaire   +3 more sources

The Effects of the Activation Energy on the Intrinsic Instability of Adiabatic and Non-Adiabatic Premixed Flames

Journal of Fluid Science and Technology, 2008
The effects of the activation energy on the intrinsic instability of adiabatic and non-adiabatic premixed flames were studied by two-dimensional unsteady calculations of reactive flows based on the compressible Navier-Stokes equation.
Amornrat KAEWPRADAP, Satoshi KADOWAKI
doaj   +3 more sources

Intrinsic instability of lean hydrogen/ammonia premixed flames: Influence of Soret effect and pressure

Fuel Communications
The addition of hydrogen in ammonia/air mixtures can lead to the onset of intrinsic flame instabilities at conditions of technical relevance. The length and time scales of intrinsic instabilities can be estimated by means of linear stability analysis of ...
F. D’Alessio, C. Matteucci, P.E. Lapenna, F. Creta   +3 more
doaj   +3 more sources

Dynamic behavior and flame acceleration of spherically expanding hydrogen flames under the low-pressure conditions

Nihon Kikai Gakkai ronbunshu, 2023
To investigate the dynamic behavior and flame acceleration of spherically expanding hydrogen flames under the low-pressure conditions, the deflagration experiments were conducted in a closed combustion chamber. The dynamic behavior of hydrogen flames was
Toshiyuki KATSUMI, Shinya YAZAWA, Masashi KUMADA, Daisuke SATO, Satoshi KADOWAKI   +4 more
doaj   +1 more source

INTRINSIC INSTABILITY OF CORONAL STREAMERS [PDF]

The Astrophysical Journal, 2009
Plasma blobs are observed to be weak density enhancements as radially stretched structures emerging from the cusps of quiescent coronal streamers. In this paper, it is suggested that the formation of blobs is a consequence of an intrinsic instability of coronal streamers occurring at a very localized region around the cusp.
Chen, Y., Li, X., Song, H. Q., Shi, Q. Q., Feng, S. W., Xia, L. D.   +5 more
openaire   +2 more sources

The effects of addition of carbon dioxide and water vapor on the dynamic behavior of spherically expanding hydrogen/air premixed flames

Journal of Thermal Science and Technology, 2021
Utilizing efficiently and securely hydrogen as clean energy source, it is required not only to analyze the experimental data under a certain condition but also to create the mathematical model for the prediction of flame propagation velocity under ...
Toshiyuki KATSUMI, Yasuhito YOSHIDA, Ryo NAKAGAWA, Shinya YAZAWA, Masashi KUMADA, Daisuke SATO, Thwe Thwe Aung, Nabiha CHAUMEIX, Satoshi KADOWAKI   +8 more
doaj   +1 more source

Effects of pressure and heat loss on the unstable motion of cellular-flame fronts caused by intrinsic instability in hydrogen-air lean premixed flames

Journal of Thermal Science and Technology, 2021
Effects of pressure and heat loss on the unstable motion of cellular-flame fronts in hydrogen-air lean premixed flames were numerically investigated. We adopted the reaction mechanism for hydrogen-oxygen combustion, modeled with seventeen reversible ...
Satoshi KADOWAKI, Thwe Thwe Aung, Taisei FURUYAMA, Kazumasa KAWATA, Toshiyuki KATSUMI, Hideaki KOBAYASHI   +5 more
doaj   +1 more source

The shape and fluctuation of hydrogen-propane-butane-air lean premixed flames formed on a flat flame burner

Journal of Thermal Science and Technology, 2021
In this paper, the characteristics of hydrogen-propane-butane-air lean premixed flames on a flat flame burner were experimentally studied. To elucidate the shape and fluctuation of premixed flames, the cell width, RMS of fluctuation, peak frequency and ...
Satoshi NAKATSURU, Amornrat KAEWPRADAP, Ryosuke NOGI, Toshiyuki KATSUMI, Daisuke SATO, Satoshi KADOWAKI   +5 more
doaj   +1 more source

Intrinsic Instability of Aberration-Corrected Electron Microscopes [PDF]

Physical Review Letters, 2012
Aberration-corrected microscopes with sub-atomic resolution will impact broad areas of science and technology. However, the experimentally observed lifetime of the corrected state is just a few minutes. Here we show that the corrected state is intrinsically unstable; the higher its quality, the more unstable it is.
Schramm, S., Molen, S.J. van der, Tromp, R.M.   +2 more
openaire   +4 more sources