Results 41 to 50 of about 112,558 (261)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Revealing violations of macrorealism in flavor oscillations: Leggett-Garg inequalities and no-signaling-in-time conditions [PDF]

EPJ Web of Conferences
. We briefly review recent developments in the study of the quantum nature of flavor mixing; in particular, the attention will be devoted to neutrino and neutral meson oscillations.
Blasone Massimo, Illuminati Fabrizio, Petruzziello Luciano, Simonov Kyrylo, Smaldone Luca   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Effects of inert gas addition on the characteristics of spherically expanding hydrogen-methane-air premixed flames in closed combustion vessels

Journal of Thermal Science and Technology
In the serious accident at Fukushima Daiichi Nuclear Power Station, the presence of steam together with flammable organic compounds affected the hydrogen explosion. To investigate the effects of addition of inert gas, i.e.
Toshiyuki KATSUMI, Atsushi ZEMBA, Makoto KOGISHI, Kohei IWANAGA, Satoshi ABE, Pascal DIÉVART, Nabiha CHAUMEIX, Satoshi KADOWAKI   +7 more
doaj   +1 more source

Yeast Assay Highlights the Intrinsic Genomic Instability of Human PML Intron 6 over Intron 3 and the Role of Replication Fork Proteins. [PDF]

PLoS ONE, 2015
Human acute promyelocytic leukemia (APL) is characterized by a specific balanced translocation t(15;17)(q22;q21) involving the PML and RARA genes. In both de novo and therapy-related APL, the most frequent PML breakpoints are located within intron 6, and
Roland Chanet, Guy Kienda, Amélie Heneman-Masurel, Laurence Vernis, Bruno Cassinat, Philippe Guardiola, Pierre Fenaux, Christine Chomienne, Meng-Er Huang   +8 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Shifted intrinsic connectivity of central executive and salience network in borderline personality disorder

Frontiers in Human Neuroscience, 2013
Borderline personality disorder (BPD) is characterized by stable instability of emotions and behavior and their regulation. This emotional and behavioral instability corresponds with a neurocognitive triple network model of psychopathology, which ...
Anselm eDoll, Anselm eDoll, Anselm eDoll, Anselm eDoll, Christian eSorg, Christian eSorg, Christian eSorg, Andrei eManoliu, Andrei eManoliu, Andrei eManoliu, Chun eMeng, Chun eMeng, Chun eMeng, Andreas eWöller, Hans eFörstl, Claus eZimmer, Afra eWohlschläger, Afra eWohlschläger, Valentin eRiedl, Valentin eRiedl, Valentin eRiedl   +20 more
doaj   +1 more source