Results 51 to 60 of about 117,106 (293)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Revealing violations of macrorealism in flavor oscillations: Leggett-Garg inequalities and no-signaling-in-time conditions [PDF]

EPJ Web of Conferences
. We briefly review recent developments in the study of the quantum nature of flavor mixing; in particular, the attention will be devoted to neutrino and neutral meson oscillations.
Blasone Massimo, Illuminati Fabrizio, Petruzziello Luciano, Simonov Kyrylo, Smaldone Luca   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Yeast Assay Highlights the Intrinsic Genomic Instability of Human PML Intron 6 over Intron 3 and the Role of Replication Fork Proteins. [PDF]

PLoS ONE, 2015
Human acute promyelocytic leukemia (APL) is characterized by a specific balanced translocation t(15;17)(q22;q21) involving the PML and RARA genes. In both de novo and therapy-related APL, the most frequent PML breakpoints are located within intron 6, and
Roland Chanet, Guy Kienda, Amélie Heneman-Masurel, Laurence Vernis, Bruno Cassinat, Philippe Guardiola, Pierre Fenaux, Christine Chomienne, Meng-Er Huang   +8 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Shifted intrinsic connectivity of central executive and salience network in borderline personality disorder

Frontiers in Human Neuroscience, 2013
Borderline personality disorder (BPD) is characterized by stable instability of emotions and behavior and their regulation. This emotional and behavioral instability corresponds with a neurocognitive triple network model of psychopathology, which ...
Anselm eDoll, Anselm eDoll, Anselm eDoll, Anselm eDoll, Christian eSorg, Christian eSorg, Christian eSorg, Andrei eManoliu, Andrei eManoliu, Andrei eManoliu, Chun eMeng, Chun eMeng, Chun eMeng, Andreas eWöller, Hans eFörstl, Claus eZimmer, Afra eWohlschläger, Afra eWohlschläger, Valentin eRiedl, Valentin eRiedl, Valentin eRiedl   +20 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Effects of inert gas addition on the characteristics of spherically expanding hydrogen-methane-air premixed flames in closed combustion vessels

Journal of Thermal Science and Technology
In the serious accident at Fukushima Daiichi Nuclear Power Station, the presence of steam together with flammable organic compounds affected the hydrogen explosion. To investigate the effects of addition of inert gas, i.e.
Toshiyuki KATSUMI, Atsushi ZEMBA, Makoto KOGISHI, Kohei IWANAGA, Satoshi ABE, Pascal DIÉVART, Nabiha CHAUMEIX, Satoshi KADOWAKI   +7 more
doaj   +1 more source