Results 51 to 60 of about 1,199,165 (253)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Modified Arthroscopic Volar Scapholunate Capsuloligamentous Repair in Chronic Severe but Reducible Volar Scapholunate Instability

Arthroscopy Techniques
The scapholunate complex is composed of the intrinsic scapholunate ligament and the surrounding extrinsic ligamentous system on the dorsal and volar sides of the wrist.
Chul Ki Goorens, M.D., Kjell Van Royen, M.D.   +1 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Coupling of acoustic and intrinsic modes in 1-D combustor models [PDF]

, 2019
The work is concerned with the theoretical examination of a new type of thermo-acoustic instability in combustors not reported in the literature. The instability results from linear coupling between the conventional acoustic mode and the recently ...
Shrira, Victor, Mukherjee, Nalini Kanta
core   +1 more source

A Chaotic State in the Transition From Single Toward Multiple Pulse for Soliton Fiber Lasers

IEEE Photonics Journal, 2020
High-order soliton in anomalous-dispersion ultrafast fiber lasers is rarely researched due to its intrinsic instability in dissipative systems. For the first time, we numerically demonstrate the ultrafast pulse in fiber lasers will deviate from the ...
Yueqing Du, Mengmeng Han, Xuewen Shu
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A matrix stability analysis of the carbuncle phenomenon [PDF]

, 2004
The carbuncle phenomenon is a shock instability mechanism which ruins all efforts to compute grid-aligned shock waves using low-dissipative upwind schemes.
Dumbser, Michaël, Moschetta, Jean-Marc, Gressier, Jérémie   +2 more
core   +1 more source

EEG state-trajectory instability and speed reveal global rules of intrinsic spatiotemporal neural dynamics.

PLoS ONE, 2020
Spatiotemporal dynamics of EEG/MEG (electro-/magneto-encephalogram) have typically been investigated by applying time-frequency decomposition and examining amplitude-amplitude, phase-phase, or phase-amplitude associations between combinations of ...
Melisa Menceloglu, Marcia Grabowecky, Satoru Suzuki   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source