Results 61 to 70 of about 4,602,806 (291)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Method of calculation of thermal loss energy in double and triple glass packaging
Қарағанды университетінің хабаршысы. Физика сериясы, 2018 The paper presents a method of calculating the heat energy loss from the room through double and triple glazing. In this article algorithms of calculation of losses of energy through the processes of conduction, convection and radiation heat transfer ...
A.S. Kudussov +4 more
doaj
Experimental determination of natural convection heat transfer coefficients in an attic shaped enclosure [PDF]
, 2010 Heat transfer by natural convection in triangular enclosures is an area of significant importance in applications such as the design of greenhouses, attics and solar water heaters.
Carson, James K. +2 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The effectiveness of heating of housing unit by renewable energy source
Research in Agricultural Engineering, 2016 The paper is aimed at pointing out possibilities of using of dendromass for heating. The object of interest was heating of housing units with 75.27 m2 of total area. The average value of dendromass moisture was 17.71%.
J. Jobbágy, K. Krištof, M. Andacký
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Journal of Fluid Science and Technology, 2008 The effects of the activation energy on the intrinsic instability of adiabatic and non-adiabatic premixed flames were studied by two-dimensional unsteady calculations of reactive flows based on the compressible Navier-Stokes equation.
Amornrat KAEWPRADAP, Satoshi KADOWAKI
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Heat Loss Measurement Using Infrared Imaging
, 1983 Infrared thermography has proven to be an important tool in numerous plant maintenance and energy conservation applications. Quantitative measurement, using infrared imaging instruments, is a powerful new dimension of infrared thermography that is ...
Seeber, S. A.
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source