Results 61 to 70 of about 633,276 (268)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Optimisation of Heat Loss through Ventilation for Residential Buildings

open access: yesAtmosphere, 2018
This study presents the results of research on heat loss from various types of residential buildings through ventilation systems. Experimental research was done to analyse the effectiveness of ventilation systems of different types and determine the ...
Dariusz Suszanowicz
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

EFFECT OF USING INTERNAL PACKAGING MATERIALS FOR NEW BUILDING WALLS ON HEATING LOAD

open access: yesJournal of Engineering and Sustainable Development, 2017
Experimental and theoretical investigation of three types of internal packaging materials(PVC, MDF, Gypsum board) for the residential building was carried out in the present work, to reduce the heating load in winter. Experiments were carried out at the
Hassan Kareem Abdullah   +1 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Studi Numerik Pengaruh Kecepatan Angin Terhadap Critical Radius dan Distribusi Temperatur Pada Pipa Uap

open access: yesJurnal Teknik ITS, 2015
Umumnya transmisi uap panas menggunakan pipa dengan diameter yang besar. Pada transmisi uap panas tersebut, kehilangan panas dan penurunan temperatur selalu terjadi.
Eka Arisma Setyo Nugroho   +1 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

GENERAL MODEL OF RADIATIVE AND CONVECTIVE HEAT TRANSFER IN BUILDINGS: PART I: ALGEBRAIC MODEL OF RADIATIVE HEAT TRANSFER

open access: yesActa Polytechnica, 2019
Radiative heat transfer is the most effective mechanism of energy transport inside buildings. One of the methods capable of computing the radiative heat transport is based on the system of algebraic equations.
Tomáš Ficker
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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