Role of heat shock protein 60 in primed and naïve states of human pluripotent stem cells. [PDF]
PLoS ONE, 2022 Human pluripotent stem cells (hPSCs) exist in at least two distinct states in mammals: naïve pluripotency that represents several molecular characteristics in pre-implantation epiblast and primed pluripotency that corresponds to cells poised for ...
Hong Seo Choi +3 more
doaj +2 more sources
Clinicopathologic significance of heat shock protein 60 as a survival predictor in breast carcinoma [PDF]
Frontiers in OncologyBackgroundWhile Heat Shock Protein 60 (HSP60) has been linked to human tumor, its clinic significance specifically in breast carcinoma is unclear. This investigation aims to retrospectively evaluate how HSP60 protein levels relate to survival outcomes ...
Qing Wang +3 more
doaj +2 more sources
Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]
Cell Death Differ, 2020 To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju +13 more
core +2 more sources
Tolerization against atherosclerosis using heat shock protein 60. [PDF]
Cell Stress Chaperones, 2016 Atherosclerosis is a chronic inflammatory disease of the artery wall, and both innate and adaptive immunity play important roles in the pathogenesis of this disease. In several experimental and human experiments of early atherosclerotic lesions, it has been shown that the first pathogenic event in atherogenesis is intimal infiltration of T cells at ...
Wick C.
europepmc +4 more sources
Heat Shock Protein 60, Insights to Its Importance in Histoplasma capsulatum: From Biofilm Formation to Host-Interaction [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Heat shock proteins (Hsps) are among the most widely distributed and evolutionary conserved proteins, acting as essential regulators of diverse constitutive metabolic processes.
Nathália Ferreira Fregonezi +8 more
doaj +2 more sources
Physical Exercise Enhanced Heat Shock Protein 60 Expression and Attenuated Inflammation in the Adipose Tissue of Human Diabetic Obese [PDF]
Frontiers in Endocrinology, 2018 Heat shock protein 60 (HSP60) is a key protein in the crosstalk between cellular stress and inflammation. However, the status of HSP60 in diabetes and obesity is unclear.
Abdelkrim Khadir +6 more
doaj +2 more sources
Heat shock protein 60 regulates yolk sac erythropoiesis in mice. [PDF]
Cell Death Dis, 2019 AbstractThe yolk sac is the first site of blood-cell production during embryonic development in both murine and human. Heat shock proteins (HSPs), including HSP70 and HSP27, have been shown to play regulatory roles during erythropoiesis. However, it remains unknown whether HSP60, a molecular chaperone that resides mainly in mitochondria, could also ...
Duan Y +12 more
europepmc +4 more sources
Vitamin D supplementation and serum heat shock protein 60 levels in patients with coronary heart disease: a randomized clinical trial [PDF]
Nutrition & Metabolism, 2018 Background The aim in this study was to investigate the effect of vitamin D (25(OH)D3) supplementation on heat shock protein 60 (HSP 60) and other inflammatory markers (IL-17, TNF-α, PAB) in patients with coronary heart disease (CHD).
Leila Sadat Bahrami +6 more
doaj +2 more sources
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer. [PDF]
PLoS ONE, 2014 Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with
Xiao-shan Li +3 more
doaj +2 more sources
Chlamydia trachomatis, Chlamydial Heat Shock Protein 60 and Anti-Chlamydial Antibodies in Women with Epithelial Ovarian Tumors [PDF]
Translational Oncology, 2018 OBJECTIVE: Chlamydia trachomatis (C. trachomatis) infection has been suggested to promote epithelial ovarian cancer (EOC) development. This study sought to explore the presence of C.
Sarah Jonsson +4 more
doaj +2 more sources