Results 21 to 30 of about 177,270 (246)

Comprehensive Pan-Cancer Analysis of Heat Shock Protein 110, 90, 70, and 60 Families

Frontiers in Molecular Biosciences, 2021
Background: Here we carried out a panoramic analysis of the expression and prognosis of HSP110, HSP90, HSP70, and HSP60 families in 33 types of cancer, with the aim of deepening the systematic understanding of heat shock proteins (HSPs) in cancer ...
Li-rong Yan, Shi-xuan Shen, Ang Wang, Han-xi Ding, Ying-nan Liu, Yuan Yuan, Qian Xu   +6 more
doaj   +1 more source

Cytosolic Heat Shock Protein 60, Hypoxia, and Apoptosis [PDF]

Circulation, 2002
Background— Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We
S, Gupta, A A, Knowlton
openaire   +2 more sources

Heat Shock Protein 60 and Immune Inflammatory Responses in Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2011
Hallmarks of inflammation in various cardiovascular diseases, notably atherosclerosis, have been observed for a long time. However, evidence for an (auto)antigen-driven process at these sites of inflammation has come forward only recently. Heat shock proteins (HSPs) have been identified as playing either immunologically mediated disease promoting or ...
Grundtman, C., Kreutmayer, S. B., Almanzar, G., Wick, M. C., Wick, G.   +4 more
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Heat Shock Protein 60: A Marker of Cardiovascular Diseases in Type 2 Egyptian Diabetic Patients [PDF]

Journal of Advanced Pharmacy Research, 2017
Background: Hyperglycaemia and hyperinsulinaemia, hallmarks of the postprandial state, have been associated with increased oxidative stress contributing to vascular injury.
Heba Taha, Sahar Abd El-mohsen Ali, Ashraf Ami, Zeinab Hassan.   +3 more
doaj   +1 more source

Cord blood CD4+ T cells respond to self heat shock protein 60 (HSP60). [PDF]

PLoS ONE, 2011
BACKGROUND: To prevent harmful autoimmunity most immune responses to self proteins are controlled by central and peripheral tolerance. T cells specific for a limited set of self-proteins such as human heat shock protein 60 (HSP60) may contribute to ...
Joost A Aalberse, Berber Kapitein, Sytze de Roock, Mark R Klein, Wilco de Jager, Ruurd van der Zee, Maarten O Hoekstra, Femke van Wijk, Berent J Prakken   +8 more
doaj   +1 more source

Involvement of heat shock proteins 60 in acetyl salicylic acid radioprotection of Albino rat submandibular salivary gland

Journal of Radiation Research and Applied Sciences, 2015
The radioprotective effect of acetyl salicylic acid against radiation injury to rat salivary glands was reported but its interrelationship with the expression of heat shock protein 60; an endogenous cytoprotectant against various stressful stimuli has ...
D.G. Mohamed, R.M. Amin
doaj   +1 more source

Heat Shock Protein-60 and Risk for Cardiovascular Disease

Current Pharmaceutical Design, 2011
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecular chaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60, the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions ...
Manfredi, Rizzo, Alberto J L, Macario, Everly Conway, de Macario, Ioanna, Gouni-Berthold, Heiner K, Berthold, Giovam Battista, Rini, Giovanni, Zummo, Francesco, Cappello   +7 more
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Detection of shared antigenic determinants between Mycobacterium leprae heat shock protein 65 and human heat shock protein 60

Hansenologia Internationalis, 2003
In these studies, it was investigated whether M. leprae and man share antigenic determinants which may be located on Heat Shock Proteins (HSPs), and which may be responsible for tissue destruction.
David Njoo, Ricardo.V.P. Hu, Bhupendra Tank, Arend.H.J. Kolk, Angela Kooy, René Kant, Bernard Naafs   +6 more
doaj   +1 more source

Autophagy protects monocytes from Wolbachia heat shock protein 60-induced apoptosis and senescence. [PDF]

PLoS Neglected Tropical Diseases, 2015
Monocyte dysfunction by filarial antigens has been a major mechanism underlying immune evasion following hyporesponsiveness during patent lymphatic filariasis. Recent studies have initiated a paradigm shift to comprehend the immunological interactions of
Vijayan Kamalakannan, Abijit Shiny, Subash Babu, Rangarajan Badri Narayanan   +3 more
doaj   +1 more source

On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60 [PDF]

Cell Stress & Chaperones, 2006
The heat shock chaperones mortalin/mitochondrial heat shock protein 70 (mtHsp70) and Hsp60 are found in multiple subcellular sites and function in the folding and intracellular trafficking of many proteins. The chaperoning activity of these 2 proteins involves different structural and functional mechanisms.
Custer C, Deocaris, Sunil C, Kaul, Renu, Wadhwa   +2 more
openaire   +2 more sources