Induction of Dendritic Cell–Mediated Activation of T Cells From Atherosclerotic Plaques by Human Heat Shock Protein 60 [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundAtherosclerosis is characterized by the presence of activated immune‐competent cells including dendritic cells (DCs) and T cells, dead cells, and oxidized low‐density lipoprotein.
Mizanur Rahman +5 more
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Differential expression of heat shock protein 90, 70, 60 in chicken muscles postmortem and its relationship with meat quality [PDF]
Asian-Australasian Journal of Animal Sciences, 2017 Objective The aim of this study was to investigate the expression of heat shock protein (HSP) 90, 70, and 60 in chicken muscles and their possible relationship with quality traits of meat. Methods The breast muscles from one hundred broiler chickens were
Muhan Zhang +7 more
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Levels of Hsp60 in periodontal tissue of rats: influence of injections of hyaluronic acid
Medičnì Perspektivi, 2021 Heat shock protein 60 (Hsp60) is considered as one of the possible autoantigens involved in the pathogenesis of a number of chronic diseases including periodontal diseases.
O.V. Kopchak +7 more
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Heat Shock Protein 60: Specific Binding of Lipopolysaccharide [PDF]
The Journal of Immunology, 2005 Abstract Human heat shock protein 60 (HSP60) has been shown to bind to the surface of innate immune cells and to elicit a proinflammatory response. In this study we demonstrate that the macrophage stimulatory property of recombinant human HSP60 is tightly linked to the HSP60 molecule and is lost after protease treatment.
Habich, C. +6 more
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Cytosolic Heat Shock Protein 60, Hypoxia, and Apoptosis [PDF]
Circulation, 2002 Background— Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We
S, Gupta, A A, Knowlton
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Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study [PDF]
, 2006 Background: Inflammation is a significant component of atherosclerosis lesions. Bacteria, including periodontopathogens, have been demonstrated in atherosclerotic plaques and cross-reactivity of the immune response to bacterial GroEL with human heat ...
Ford, P. J. +8 more
core +3 more sources
Comprehensive Pan-Cancer Analysis of Heat Shock Protein 110, 90, 70, and 60 Families
Frontiers in Molecular Biosciences, 2021 Background: Here we carried out a panoramic analysis of the expression and prognosis of HSP110, HSP90, HSP70, and HSP60 families in 33 types of cancer, with the aim of deepening the systematic understanding of heat shock proteins (HSPs) in cancer ...
Li-rong Yan +6 more
doaj +1 more source
Extracellular Heat Shock Protein 60, Cardiac Myocytes, and Apoptosis [PDF]
Circulation Research, 2009 Rationale: Previously, we have found that changes in the location of intracellular heat shock protein (HSP)60 are associated with apoptosis. HSP60 has been reported to be a ligand of Toll-like receptor (TLR)-4.
Se-Chan, Kim +8 more
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Lipopolysaccharide-free Heat Shock Protein 60 Activates T Cells [PDF]
Journal of Biological Chemistry, 2004 A possible function of eukaryotic heat shock protein 60 (Hsp60) as endogenous danger signal has been controversially discussed in the past. Hsp60 was shown to induce the secretion of proinflammatory cytokines in professional antigen-presenting cells and to enhance the activation of T cells in primary stimulation.
Anke, Osterloh +5 more
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Cord blood CD4+ T cells respond to self heat shock protein 60 (HSP60). [PDF]
PLoS ONE, 2011 BACKGROUND: To prevent harmful autoimmunity most immune responses to self proteins are controlled by central and peripheral tolerance. T cells specific for a limited set of self-proteins such as human heat shock protein 60 (HSP60) may contribute to ...
Joost A Aalberse +8 more
doaj +1 more source