Results 101 to 110 of about 413,998 (350)

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

The relationship of Heat Shock Protein-70(HSP-70) and toxoplasmosis among women with abortion

Kufa Journal for Nursing Sciences, 2012
Background: Toxoplasmosis is a wide spread disease in our society, moreover it plays an important role in causation of abortion in pregnant women. Objectives: The present study was carried out to evaluate the role of Heat Shock Protein-70 (HSP-70) in ...
Kareem Mohammed, Baqur Sultan, Salman Al-Jobouri, Hanaa Al-Sagheer   +3 more
doaj   +1 more source

Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]

, 2014
The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher, Munje, Chinmay, Shervington, Amal A, Shervington, Leroy Alexander   +3 more
core   +2 more sources

Nitric Oxide Protects Cultured Rat Hepatocytes from Tumor Necrosis Factor-α-induced Apoptosis by Inducing Heat Shock Protein 70 Expression*

Journal of Biological Chemistry, 1997
Nitric oxide (NO) and tumor necrosis factor-α (TNFα) play important roles in the pathogenesis of liver disease during acute inflammation. The present study was designed to elucidate the effect of NO pre-exposure on TNFα-induced hepatotoxicity ...
Y. M. Kim, M. E. de Vera, Simon C Watkins, T. Billiar   +3 more
semanticscholar   +1 more source

Insulin potentiates expression of myocardial heat shock protein 70 [PDF]

European Journal of Cardio-Thoracic Surgery, 2004
Since insulin stimulates nitric oxide (NO) production and an increase in NO following heat shock is required for myocardial heat shock protein 70 (Hsp70) synthesis, we hypothesized that insulin would enhance myocardial Hsp70 synthesis by augmenting NO signaling.
Gefeng, Li, R William, Currie, Imtiaz S, Ali   +2 more
openaire   +2 more sources

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Heat shock protein 70 levels in children with nephrotic syndrome

The Turkish Journal of Pediatrics
Background. Idiopathic nephrotic syndrome (NS) is the most prevalent glomerular disease in children. Heat shock protein 70 (HSP70) is synthesized in response to diverse stress factors like infections and oxidative stress.
Bağdagül Aksu, Zeynep Nagehan Yürük Yıldırım, Asuman Gedikbaşı, Alev Yılmaz   +3 more
doaj   +1 more source

Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

The Scientific World Journal, 2014
The polymorphisms in the three main heat shock protein 70 (HSP70-1, HSP70-2, and HSP70-hom) genes were identified to be associated with cancer risk. However, the results are inconsistent. We perform a meta-analysis to evaluate the association between the
Lei He, Tao Deng, He-sheng Luo
doaj   +1 more source

Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis

Journal of Translational Medicine, 2012
Background Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.
Cai Man-Bo, Wang Xiao-Pai, Zhang Jia-Xing, Han Hui-Qiong, Liu Chao-Chun, Bei Jin-Xin, Peng Ruo-Jun, Liang Yi, Feng Qi-Sheng, Wang Hai-Yun, Chen Li-Zhen, Fu Sha, Kang Tiebang, Shao Jian-Yong, Zeng Yi-Xin   +14 more
doaj   +1 more source

Heat Shock Protein 70 and Heat Tolerance in Early-Age Feed Restricted Broiler Chickens [PDF]

, 2000
The objectives of this study are to evaluate the effect of various degree of neonatal feed restrictions on heat tolerance later in life, the importance of heat shock protein 70 (HSP 70) in eliciting thermotolerance in broilers and the relationship ...
Mat Taib, Che Norma
core