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Therapeutic Use of Heat Shock Protein 70
Recent Patents on DNA & Gene Sequences, 2007All living organisms use protein to perform essential functions. However, environmental factors induce stress and relevant proteins that may not function properly. Inappropriate misfolding and aggregation are major issues in functioning of a protein and this may impact critical cellular processes implicated in diseases.
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Archives of Dermatological Research, 1994
Autoimmunity and microbial agents have been suggested as playing a pathogenetic role in psoriasis. Since immune responses to microbial infections are often directed towards heat shock proteins (HSP), we investigated the expression of three HSP families in normal and inflamed human skin. Specimens from ten patients with psoriasis and three patients with
Boehncke, Wolf-Henning +3 more
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Autoimmunity and microbial agents have been suggested as playing a pathogenetic role in psoriasis. Since immune responses to microbial infections are often directed towards heat shock proteins (HSP), we investigated the expression of three HSP families in normal and inflamed human skin. Specimens from ten patients with psoriasis and three patients with
Boehncke, Wolf-Henning +3 more
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Multifaceted Role of Heat Shock Protein 70 in Neurons
Molecular Neurobiology, 2010Heat shock protein 70 (Hsp70) plays important roles in neural protection from stress by assisting cellular protein folding. In this review we discuss the current understanding of inducible and constitutive Hsp70 in maintaining and protecting neuronal synaptic function under normal and stressed conditions.
Tom Z, Lu, Yi, Quan, Zhong-Ping, Feng
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Heat Shock Protein 70 and Cancer
2018Heat shock proteins (HSP) constitute a large family of proteins involved in protein folding and maturation and the expressions of HSP are induced by heat shock or other stressors. The major groups, which are classified based on their molecular weight, include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSP (HSP110 and glucose-regulated protein 170 ...
Tuoen Liu, Shousong Cao
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cDNA of Canine Heat Shock Protein 70 (HSP70)
Veterinary Research Communications, 2004Full-length canine HSP70 cDNA was sequenced and the expression of HSP70 mRNA was investigated. The full-length cDNA sequence of the HSP70 gene (2322 bp) contained a single long open reading frame (1920 bp) coding a protein of 640 amino acids. The amino acid sequence of the canine HSP70 gene shared about 90-95% sequence similarity with bovine, human and
R, Kano, K, Abe, A, Hasegawa
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Immunohistochemical expression of heat shock protein 70 in vitiligo
Annals of Diagnostic Pathology, 2013Heat shock proteins (HSPs) are proteins that are expressed under variety of stresses including pathologic conditions. How stresses affect vitiligo is not fully understood and little is known about the role of HSPs generally and Hsp70 specifically in vitiligo.
Asmaa Gaber, Abdou +2 more
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Identification of heat shock protein 70 in the rabies virion
Virology, 1992We investigated a 73-kDa polypeptide (p73), a minor component of the rabies virion (HEP-Flury and ERA strains), accounting for as much as 1% of total virion proteins. Two-dimensional gel electrophoresis and immunoblotting with the antiserum against the heat shock protein 70 (hsp70) demonstrated that p73 was identical to a constitutive type of cellular ...
J, Sagara, A, Kawai
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Heat‐shock protein 70 expression in the equine cornea
Veterinary Ophthalmology, 2016AbstractObjectiveExpression of the 70‐kDa heat‐shock protein (HSP70) has been demonstrated in normal canine corneal epithelium, and inducible expression has been suggested to facilitate wound resolution through organized migration, proliferation, and adhesion of the corneal epithelial cells.
Cornelia Peterson +4 more
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Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina
2018Heat shock proteins (HSP) belong to a family of stress-induced proteins essential to cell survival. HSP have multiple protective roles through assistance in protein folding, maintaining mitochondrial homeostasis, suppressing proinflammatory cytokines, resisting ischemic damage and protecting cells from apoptotic and necrotic death.
Ting Zhang, Bobak Bahrami, Ling Zhu
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Carbenoxolone, a new inducer of heat shock protein 70
Life Sciences, 2001Heat shock protein 70 (Hsp70) is capable of protecting cells, tissues, organs, and animals from a subsequent, normally lethal heating, as well as from numerous disease states. Therefore, it would be of great therapeutic benefit to discover compounds that are clinically safe yet able to induce Hsp70 in patients.
S, Nagayama +8 more
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