Results 71 to 80 of about 153,832 (262)

Effect of Trehalose on the Expression of Heat Shock Protein 70 Gene in PC12 Cells Treated with Hydrogen Peroxide

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: Oxidative stress is implicated in the pathogenesis of various diseases, including neurological disorders. In such stressful conditions, heat shock protein 70 (HSP70) protects cells, thus its pharmacological induction can be ...
Mahdieh Nazari Robati, Akram Norouzi, Roya Nasouti   +2 more
doaj  

Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

The Scientific World Journal, 2014
The polymorphisms in the three main heat shock protein 70 (HSP70-1, HSP70-2, and HSP70-hom) genes were identified to be associated with cancer risk. However, the results are inconsistent. We perform a meta-analysis to evaluate the association between the
Lei He, Tao Deng, He-sheng Luo
doaj   +1 more source

Regulation of heat shock protein 70 synthesis by heat shock in the preimplantation murine embryo

Theriogenology, 1995
Induced thermotolerance in murine embryos occurs at the 8-cell stage when embryos are maintained in vitro but not until the blastocyst stage if development proceeds in vivo. Present results indicate that ability of embryos to undergo induced thermotolerance is not limited by heat shock protein 70 (HSP70) synthesis.
Department of Dairy and Poultry Sciences, University of Florida Gainesville FL 32611-0920, USA ( host institution ), Edwards, J.L., Ealy, A.D., Hansen, P.J.   +3 more
openaire   +3 more sources

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

The relationship of Heat Shock Protein-70(HSP-70) and toxoplasmosis among women with abortion

Kufa Journal for Nursing Sciences, 2012
Background: Toxoplasmosis is a wide spread disease in our society, moreover it plays an important role in causation of abortion in pregnant women. Objectives: The present study was carried out to evaluate the role of Heat Shock Protein-70 (HSP-70) in ...
Kareem Mohammed, Baqur Sultan, Salman Al-Jobouri, Hanaa Al-Sagheer   +3 more
doaj   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis

Journal of Translational Medicine, 2012
Background Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.
Cai Man-Bo, Wang Xiao-Pai, Zhang Jia-Xing, Han Hui-Qiong, Liu Chao-Chun, Bei Jin-Xin, Peng Ruo-Jun, Liang Yi, Feng Qi-Sheng, Wang Hai-Yun, Chen Li-Zhen, Fu Sha, Kang Tiebang, Shao Jian-Yong, Zeng Yi-Xin   +14 more
doaj   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression

Neoplasia: An International Journal for Oncology Research
Background: Glioblastoma (GBM) poses a significant medical challenge due to its aggressive nature and poor prognosis. Mitochondrial unfolded protein response (UPRmt) and the heat shock factor 1 (HSF1) pathway play crucial roles in GBM pathogenesis.
Xiang Li, Zongqi Wang, Bixi Gao, Kun Dai, Jiang Wu, Kecheng Shen, Guangzhao Li, Xiaowang Niu, Xin Wu, Longyuan Li, Haitao Shen, Haiying Li, Zhengquan Yu, Zhong Wang, Gang Chen   +14 more
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source