Results 121 to 130 of about 569,417 (300)

A dajkafehérjék az öregedési folyamatokban = Molecular chaperones in the ageing process [PDF]

, 2008
A stresszválasz fontos szerepet játszik az öregedésben, és terápiás célpont a korfüggő betegségek kezelésében. Pályázatunkban kimutattuk, hogy (1) az öregedés kóroki tényezőjeként ismert oxidatív stressz osztódó sejtekben nem vezet fehérje denaturációhoz
Amere Subbarao, Sreedhar, Csermely, Péter, Papp, Eszter, Sőti, Csaba   +3 more
core  

A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial. [PDF]

, 2017
Lessons learnedThe addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer ...
Al-Hazzouri, Ahmed, Bendell, Johanna C, DeBusk, Laura M, Earwood, Chris, Guo, Shuangli, Ko, Andrew H, Lane, Cassie M, Murphy, Patrick B, Peyton, James D, Rodriguez, Francisco A, Shipley, Dianna L, Tempero, Margaret A, Waterhouse, David M, Womack, Mark S, Xiong, Henry Q   +14 more
core   +1 more source

Pulsed Laser‐Assisted Phase Engineering of Multimetallic Colloidal Nanocrystals With Complex Compositions

Advanced Materials, EarlyView.
The engineering of colloidal nanocrystals with complex compositions has emerged as a highly active area of research within nanomaterials science. This review covers key aspects of colloidal solid‐solution nanocrystal formation using pulsed laser irradiation.
Marina T. Candela, Sergio Triviño‐Sánchez, Andrés Guerrero‐Martínez, Luis M. Liz‐Marzán, Guillermo González‐Rubio   +4 more
wiley   +1 more source

HSF1 is essential for the resistance of zebrafish eye and brain tissues to hypoxia/reperfusion injury.

PLoS ONE, 2011
Ischemia and subsequent reperfusion (IR) produces injury to brain, eye and other tissues, contributing to the progression of important clinical pathologies.
Nathan R Tucker, Ryan C Middleton, Quynh P Le, Eric A Shelden   +3 more
doaj   +1 more source

Phase Engineering of Nanomaterials (PEN): Evolution, Current Challenges, and Future Opportunities

Advanced Materials, EarlyView.
This review summarizes the synthesis, phase transition, advanced characterization spanning ex situ to in situ and operando techniques, and diverse applications of phase engineering of nanomaterials (PEN). It further outlines key challenges and future opportunities, such as phase stability, architecture control, and artificial intelligence (AI)‐driven ...
Ye Chen, Zhanxi Fan, Jingjie Ge, Qiyuan He, Zhuangchai Lai, Jiawei Liu, Chaoliang Tan, Hua Zhang   +7 more
wiley   +1 more source

Additive Manufacture of Diamond:Titanium Hybrid Quantum Sensors

Advanced Materials Interfaces, EarlyView.
ABSTRACT Additive manufacture represents one of the most advanced techniques for the creation of complex parts for applications as diverse as aerospace and implant surgery. However, a challenge with bespoke manufacture of metal parts is the incorporation of sensor elements in a fashion compatible with the 3D printing process.
Daniel Stavrevski, Marsilea A. Booth, David A. Broadway, Islay O. Robertson, Nour Mani, Joshua Zarins, Peter C. Sherrell, Amanda N. Abraham, Qiang Sun, Takeshi Ohshima, Brant C. Gibson, Kate Fox, Andrew D. Greentree   +12 more
wiley   +1 more source

Regulation of translation elongation and integrated stress response in heat-shocked neurons

Cell Reports
Summary: Neurons deviate from a canonical heat shock response (HSR). Here, we revealed that neuronal adaptation to heat shock accompanies a brake on mRNA translation, slowed elongating ribosomes, phosphorylation of eukaryotic elongation factor-2 (p-eEF2),
Caitlin M. Seluzicki, Milad Razavi-Mohseni, Fulya Türker, Priyal Patel, Boyang Hua, Michael A. Beer, Loyal Goff, Seth S. Margolis   +7 more
doaj   +1 more source

Global transcriptome analysis of the heat shock response of Bifidobacterium longum [PDF]

, 2017
Bifidobacteria are natural inhabitants of the human gastrointestinal tract and have been widely used as functional foods in different products. During industrial processing, bacterial cells undergo several stresses that can limit large-scale production ...
Arigoni, Fabrizio, Barretto, Caroline, Cuanoud, Gabriella, Delley, Michèle, Giliberti, Gabriele, Lariani, Sofiane, Pessi, Gabriella, Rezzonico, Enea   +7 more
core  

Hybrid Magnetoactive Soft Elastomers: Material Development Toward Application in Diaphragm Pumps

Advanced Materials Technologies, EarlyView.
Hybrid magnetoactive soft elastomeric membranes are developed by combining two different types of magnetic particles. The membranes exhibit distinct mechanical, magnetic and thermal properties owing to the unique characteristics of the two magnetic particles.
Somashree Mondal, Paweł Orkisz, Bogdan Sapiński, Ralph Spolenak, Frank Clemens   +4 more
wiley   +1 more source

Anti‐Slip Material‐Based Strategies and Approaches

Advanced Materials Technologies, EarlyView.
This review highlights the principle mechanisms of slipping at the microscale, linking contact mechanics with a friction behavior model for surface interfaces. Main strategies to develop anti‐slip properties to the surfaces are discussed alongside standardized testing approaches.
Sogand Abbaspoor‐Zanjani, Carlo Antonini, Teresa Gatti, Mengjiao Wang   +3 more
wiley   +1 more source