Results 131 to 140 of about 211,605 (257)

Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response. [PDF]

Nat Commun
Omkar S, Kline JT, Grissom JH, Sun D, Chi RJ, Bard JAM, Fornelli L, Truman AW.   +7 more
europepmc   +1 more source

Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models. [PDF]

Mol Neurobiol, 2023
Ahmed M, Spicer C, Harley J, Taylor JP, Hanna M, Patani R, Greensmith L.   +6 more
europepmc   +1 more source

Discovery of the heat shock response

Cell Stress & Chaperones, 1996
openaire   +3 more sources

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Conservation of mRNA operon formation in control of the heat shock response in mammalian cells. [PDF]

Sci Adv
Pataki E, Gerst JE.
europepmc   +1 more source

HSP70 mediates a crosstalk between the estrogen and the heat shock response pathways. [PDF]

J Biol Chem, 2023
Silveira MAD, Khadangi F, Mersaoui SY, Naik D, Masson JY, Bilodeau S.   +5 more
europepmc   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress. [PDF]

Nat Commun
Shukla N, Neal ML, Farré JC, Mast FD, Sarkar R, Truong L, Simon T, Miller LR, Aitchison JD, Subramani S.   +9 more
europepmc   +1 more source

Inhibition of TRAP1 Accelerates the DNA Damage Response, Activation of the Heat Shock Response and Metabolic Reprogramming in Colon Cancer Cells. [PDF]

Front Biosci (Landmark Ed), 2023
Bhasin N, Dabral P, Senavirathna L, Pan S, Chen R.   +4 more
europepmc   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source