Results 201 to 210 of about 870,730 (334)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

GLA-3 mediates the heat shock response in Caenorhabditis elegans germ cells: A key role for the tristetraprolin (TTP) family. [PDF]

PLoS One
Salinas LS, Dámazo-Hernández ÁA, Cristino-Miranda AM, Zurita-León M, Morales-Oliva E, Láscarez-Lagunas LI, Navarro RE.   +6 more
europepmc   +1 more source

Lessons Learned from Two Decades of Modeling the Heat-Shock Response. [PDF]

Biomolecules, 2022
Ranawade A, Sharma R, Levine E.
europepmc   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

The Heat Shock Response Under Natural Conditions in Two Paper Wasp Species. [PDF]

Insects
Amstrup AB, Kovac H, Käfer H, Stabentheiner A, Sørensen JG.   +4 more
europepmc   +1 more source

Genotypic-specific heat shock response of vector susceptibility to Schistosoma mansoni. [PDF]

Ecosphere, 2022
Spaan JM, Leavitt N, Shen J, Bundy T, Burrows L, Ingram C, Maehara TR, Ndungu I, Mutuku M, Owino G, Odiere M, Steinauer ML.   +11 more
europepmc   +1 more source

Additive‐Free Ti3C2Tx MXene Actuator with Large Deformation, Programmability, and High‐Humidity Stability via Precise Interlayer Spacing Control Engineering

Advanced Science, EarlyView.
By sequentially assembling MXene nanosheets with significant size differences, a multistimulus responsive additive‐free MXene actuator with gradient structure is obtained. An innovative cyclic low‐temperature annealing‐rehydration technology is proposed, which achieves precise control of interlayer d‐spacing, initial shape, and actuation behavior of ...
Haowen Zheng, Liangliang Xu, Qian Yan, Zonglin Liu, He Chen, Huanxin Lian, Yunxiang Chen, Teng Fei, Yiming Hu, Fuhua Xue, Xu Zhao, Cong Zhang, Qingyu Peng, Xiaodong He   +13 more
wiley   +1 more source

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response. [PDF]

Elife
Ruger-Herreros C, Svoboda L, Male G, Shrivastava A, Höpfler M, Jetzinger K, Koubek J, Kramer G, den Brave F, Mogk A, Gross DS, Bukau B.   +11 more
europepmc   +1 more source

The heat shock response and small molecule regulators. [PDF]

Eur J Med Chem, 2021
Kurop MK, Huyen CM, Huyen CM, Kelly JH, Blagg BSJ.   +4 more
europepmc   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source