Results 231 to 240 of about 870,730 (334)

Response and adaptation of the transcriptional heat shock response to pressure. [PDF]

Front Microbiol
Coffin CH, Fisher LA, Crippen S, Demers P, Bartlett DH, Royer CA.   +5 more
europepmc   +1 more source

Alpha-lipoic acid attenuates heat stress-induced apoptosis via upregulating the heat shock response in porcine parthenotes. [PDF]

Sci Rep, 2023
Lee SH, Sun MH, Jiang WJ, Li XH, Heo G, Zhou D, Chen Z, Cui XS.   +7 more
europepmc   +1 more source

Biology of the Heat Shock Response and Protein Chaperones: Budding Yeast (Saccharomyces cerevisiae) as a Model System

Microbiology and Molecular Reviews, 2012
J. Verghese, Jennifer L. Abrams, Yanyu Wang, K. Morano   +3 more
semanticscholar   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

A Novel Pathogenic Variant Identified in HIKESHI-Related Hypomyelinating Leukodystrophy Disrupts Heat Shock Response in iPSCs. [PDF]

Int J Mol Sci
Saleh MA, Boichuck M, Ottolenghi A, Rabinski T, Goldenthal O, Sanchez DS, Fattal-Valevski A, Heimer G, Ben-Shachar S, Libzon S, Gershoni-Yahalom O, Ben-Zvi A, Zarivach R, Zerem A, Rosental B, Vatine GD.   +15 more
europepmc   +1 more source

Glia of C. elegans coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit. [PDF]

Sci Adv, 2022
Gildea HK, Frankino PA, Tronnes SU, Pender CL, Durieux J, Dishart JG, Choi HO, Hunter TD, Cheung SS, Frakes AE, Sukarto E, Wickham K, Dillin A.   +12 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Preserve or destroy: Orphan protein proteostasis and the heat shock response. [PDF]

J Cell Biol
Ali A, Paracha S, Pincus D.
europepmc   +1 more source

Elevated Extracellular HSP72 and Blunted Heat Shock Response in Severe COVID-19 Patients. [PDF]

Biomolecules, 2022
Borges Russo MK, Kowalewski LS, da Natividade GR, de Lemos Muller CH, Schroeder HT, Bock PM, Ayres LR, Cardoso BU, Zanotto C, Schein JT, Rech TH, Crispim D, Canani LH, Friedman R, Leitão CB, Gerchman F, Krause M.   +16 more
europepmc   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source