Results 111 to 120 of about 4,037,107 (241)

Heat stress induced changes in some blood parameters in pigs

, 2021
The study's main objective was to investigate the effects of chronic HS on pigs and how they could be mitigated by dietary treatments that included antioxidant nutrients such as vitamin C, vitamin E, zinc, and selenium. The animals were divided into four
Leite Rodrigues, Marjorie
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Heat stress

, 2006
This fact sheet describes what heat stress is and how to control it.
Buffington, E. J., author, McDonald, S. K., author, Colorado Environmental Pesticide Education Program, publisher   +2 more
openaire   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Heat shock proteins in male infertility: recent advances and clinical implications

Frontiers in Cell and Developmental Biology
The decline in male sperm quality has become a global concern for male reproductive health. Research indicates that heat stress is an important external factor that contributes to male infertility, potentially promoting germ cell apoptosis, disrupting ...
Zhongnan Wu, Wanting Zhang, Ruqi Han, Huiyu Ping, Linhui Xia, Haoran Ding, Jinxiang Yuan, Xiaomei Wang, Qin Qin   +8 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Tomato heat stress transcription factor HsfB1 represents a novel type of general transcription coactivator with a histone-like motif interacting with HAC1/CBP [PDF]

, 2005
In contrast to the class A heat stress transcription factors (Hsfs) of plants, a considerable number of Hsfs assigned to classes B and C have no evident function as transcription activators on their own.
Bharti, Kapil
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

A biological study of the cellular response to heat stress in the South African alga Gracilaria gracilis [PDF]

, 2012
Includes bibliographical references.Gracilaria gracilis is a commercially important alga, previously harvested from the wild South African population in Saldanha Bay as a feed for marine organisms and as a source of commercially important agar.
Boom, Taryn
core   +1 more source

Heat stress impacts affective processes and risk-taking behaviour

Scientific Reports
The understanding of heat stress on human behaviour is critical due to increasing frequency of extreme heat events. Heat stress has been shown to detrimentally alter affective states and cognition, effects that are particularly critical for individuals ...
Jannic Wälde, Günter Amesberger, Sabine Würth, Markus Reichert, Thomas Finkenzeller   +4 more
doaj   +1 more source