Results 91 to 100 of about 4,787,888 (297)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Breeding for improved heat tolerance in dairy cattle: Methods, challenges, and progress*

JDS Communications
Heat tolerance in dairy cattle has likely deteriorated over time due to unfavorable genetic correlations between milk production level and heat tolerance, with stronger deterioration in later parities.
Ignacy Misztal, Luiz F. Brito, Daniela Lourenco   +2 more
doaj   +1 more source

Survival of heat stress with and without heat hardening in Drosophila melanogaster: interactions with larval density [PDF]

, 2012
Survival of a potentially lethal high temperature stress is a genetically variable thermal adaptation trait in many organisms. Organisms cope with heat stress by basal or induced thermoresistance.
Loeschcke, Volker, Norry, Fabian Marcelo, Arias, Leticia Noemi, Sambucetti, Pablo Daniel, Scannapieco, Alejandra Carla   +4 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Male Parent Plays More Important Role in Heat Tolerance in Three-Line Hybrid Rice

Rice Science, 2015
Ten F1 combinations with their male and female parents were employed to evaluate their heat tolerance during the flowering and early grain filling stages. The rice plants were subjected to heat stress (39 °C–43 °C) for 1–15 d during flowering.
Fu Guan-fu, Zhang Cai-xia, Yang Yong-jie, Xiong Jie, Yang Xue-qin, Zhang Xiu-fu, Jin Qian-yu, Tao Long-xing   +7 more
doaj   +1 more source

Heat-Stress Preparedness

Heat-Stress Preparedness: Increasing the resilience and adaptation of UK cities to heat-stress.This policy briefing paper was produced by the Surface Temperature team at the University of Leicester, with the support of the University of Leicester ...
Rocio Barrio Guillo (20335575), University of Leicester Surface Temperature Group (21385422), University of Leicester Institute for Policy (21384525)   +2 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Heat stress in horses: a literature review

, 2023
Healthy adult horses can balance accumulation and dissipation of body heat to maintain their body temperature between 37.5 and 38.5 °C, when they are in their thermoneutral zone (5 to 25 °C). However, under some circumstances, such as following strenuous
Rebeka R. Zsoldos, Narayan, Edward, Sole-Guitart, Albert, John B. Gaughan, Zsoldos, Rebeka R, Hyungsuk Kang, Edward Narayan, Gaughan, John B, Albert Sole-Guitart, A. Judith Cawdell-Smith, Kang, Hyungsuk, Cawdell-Smith, A Judith   +11 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source