Results 71 to 80 of about 4,037,107 (241)

Adaptive memory induced by heat stress during grain filling enhances subsequent thermotolerance in rice (Oryza sativa L.)

Scientific Reports
Rice grain chalkiness occurs when grains fill under heat stress, greatly reducing grain quality. But the effects of heat stress during grain filling on the subsequent development and adaptive traits remain to be elucidated. Here, we evaluated the effects
Chetphilin Suriyasak, Ryosuke Kawaguchi, Ryo Matsumoto, Yuta Sawada, Hue Thi Nong, Norimitsu Hamaoka, Yushi Ishibashi   +6 more
doaj   +1 more source

Mapping responsive genomic elements to heat stress in a maize diversity panel

Genome Biology, 2022
Background Many plant species exhibit genetic variation for coping with environmental stress. However, there are still limited approaches to effectively uncover the genomic region that regulates distinct responsive patterns of the gene across multiple ...
Zhikai Liang, Zachary A. Myers, Dominic Petrella, Julia Engelhorn, Thomas Hartwig, Nathan M. Springer   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effects of dietary changes on heat stress in broiler and Kampung chickens [PDF]

, 2012
Poultry meat production has increased drastically over the last 35 years. Most developing countries are in the tropics and often have high ambient temperatures.
Syafwan, W.
core  

Heat stress adaptations in pigs [PDF]

Animal Frontiers, 2018
Heat stress adaptations in ...
Mayorga, Edith, Renaudeau, David, Ramirez, Brett, Ross, Jason, Baumgard, Lance   +4 more
openaire   +4 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Heat acclimation for protection from exertional heat stress [PDF]

, 2016
This is the protocol for a review and there is no abstract. The objectives are as follows:\ud \ud To assess the effects of heat acclimation interventions aimed at protecting health and performance from exertional heat ...
Skein, Melissa, Minett, GM, Stewart, Ian B., Costello, Joseph, Bieuzen, F, Stewart, IB, Borg, DN, Borg, David N., Bieuzen, Francois, Costello, JT, Bach, Aaron J.E., Costello, Joseph T., Skein, M, Bach, AJE, Minett, Geoffrey M.   +14 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Time-series transcriptomic analysis of flower tissue during heat stress in heat-resilient and heat-sensitive Brassica napus L.

Frontiers in Genetics
Brassica napus a cool-season oilseed crop, is an important source of edible oil and biofuel. Heat stress during the reproductive stage poses a serious threat to its productivity, but little is known about the gene networks involved in the heat stress ...
Xiaojie Hu, Xiaojie Hu, Sheng Chen, Sheng Chen, Xiaoke Ping, Xiaoke Ping, Kadambot H. M. Siddique, Kadambot H. M. Siddique, Wallace A. Cowling, Wallace A. Cowling   +9 more
doaj   +1 more source