Results 71 to 80 of about 4,787,888 (297)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Consideration of residual stress and geometry during heat treatment to decrease shaft bending [PDF]

, 2014
In automotive industry, heat treatment of components is implicitly related to distortion. This phenomenon is particularly obvious in the case of gearbox parts because of their typical geometry and precise requirements.
SURA, Edoardo, BIGOT, Regis, HUSSON, Rémi, BAUDOUIN, Cyrille   +3 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Adaptive memory induced by heat stress during grain filling enhances subsequent thermotolerance in rice (Oryza sativa L.)

Scientific Reports
Rice grain chalkiness occurs when grains fill under heat stress, greatly reducing grain quality. But the effects of heat stress during grain filling on the subsequent development and adaptive traits remain to be elucidated. Here, we evaluated the effects
Chetphilin Suriyasak, Ryosuke Kawaguchi, Ryo Matsumoto, Yuta Sawada, Hue Thi Nong, Norimitsu Hamaoka, Yushi Ishibashi   +6 more
doaj   +1 more source

Mapping responsive genomic elements to heat stress in a maize diversity panel

Genome Biology, 2022
Background Many plant species exhibit genetic variation for coping with environmental stress. However, there are still limited approaches to effectively uncover the genomic region that regulates distinct responsive patterns of the gene across multiple ...
Zhikai Liang, Zachary A. Myers, Dominic Petrella, Julia Engelhorn, Thomas Hartwig, Nathan M. Springer   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Effects of Drought, Heat and Their Interaction on the Growth, Yield and Photosynthetic Function of Lentil (Lens culinaris Medikus) Genotypes Varying in Heat and Drought Sensitivity

Frontiers in Plant Science, 2017
Rising temperatures and drought stress limit the growth and production potential of lentil (Lens culinaris Medikus), particularly during reproductive growth and seed filling.
Akanksha Sehgal, Kumari Sita, Jitendra Kumar, Shiv Kumar, Sarvjeet Singh, Kadambot H. M. Siddique, Harsh Nayyar   +6 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Time-series transcriptomic analysis of flower tissue during heat stress in heat-resilient and heat-sensitive Brassica napus L.

Frontiers in Genetics
Brassica napus a cool-season oilseed crop, is an important source of edible oil and biofuel. Heat stress during the reproductive stage poses a serious threat to its productivity, but little is known about the gene networks involved in the heat stress ...
Xiaojie Hu, Xiaojie Hu, Sheng Chen, Sheng Chen, Xiaoke Ping, Xiaoke Ping, Kadambot H. M. Siddique, Kadambot H. M. Siddique, Wallace A. Cowling, Wallace A. Cowling   +9 more
doaj   +1 more source