Results 81 to 90 of about 4,037,107 (241)
Some aspects of heat stress on the plasticity of skeletal muscle cells
Journal of Physical Fitness and Sports Medicine, 2012 Hypertrophic stimuli, such as strength training and exercise, induce the up-regulation of heat shock proteins (HSPs), called stress proteins, in skeletal muscles.
Katsumasa Goto +12 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
, 2017 Heat stress is one of the most important environmental stressors that reduce productivity in animal breeding. The productivity of farm animals is significantly reduced due to temperature increases. As a result, significant economic losses occur during the summer months.
Sireli, Halit Deniz +3 more
openaire +3 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Indicators of physiological stress and the elaboration of sexual traits in the collared flycatcher [PDF]
, 2006 Stress may have consequences for the evolution of condition-dependent sexual traits. For example, stress may be related to sexual traits through immune function, and sexual traits can reflect how individuals bear the costs of stress-mediated ...
Török, János +12 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Effect of short-term heat stress on the immune function of chickens: a review
, 1999 Previous studies indicated that exposure to heat stress for a short duration often adversely affected humoral and/or cell-mediated immunity in chickens.
Al-Bisher, Abdul Aziz A. +2 more
core
Breeding for improved heat tolerance in dairy cattle: Methods, challenges, and progress*
JDS CommunicationsHeat tolerance in dairy cattle has likely deteriorated over time due to unfavorable genetic correlations between milk production level and heat tolerance, with stronger deterioration in later parities.
Ignacy Misztal +2 more
doaj +1 more source