Results 81 to 90 of about 4,787,888 (297)

Short- and Long-Term Biomarkers for Bacterial Robustness: A Framework for Quantifying Correlations between Cellular Indicators and Adaptive Behavior [PDF]

, 2010
The ability of microorganisms to adapt to changing environments challenges the prediction of their history-dependent behavior. Cellular biomarkers that are quantitatively correlated to stress adaptive behavior will facilitate our ability to predict the ...
Heidi M S Gaballo, Moezelaar, R., Abee, T., Heidy M. W. den Besten, Marcel H Zwietering, Aarathi Arvind, Heidy M W den Besten, Gaballo, H.M.S., Roy Moezelaar, Heidi M. S. Gaballo, Tjakko Abee, Besten, H.M.W., den, Arvind, A., Zwietering, M.H., Marcel H. Zwietering, den Besten Heidy M. W., Abee Tjakko, Gaballo Heidi M. S., Moezelaar Roy, Arvind Aarathi, Zwietering Marcel H.   +20 more
core   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Some aspects of heat stress on the plasticity of skeletal muscle cells

Journal of Physical Fitness and Sports Medicine, 2012
Hypertrophic stimuli, such as strength training and exercise, induce the up-regulation of heat shock proteins (HSPs), called stress proteins, in skeletal muscles.
Katsumasa Goto, Yoshitaka Ohno, Ayumi Goto, Akihiro Ikuta, Miho Suzuki, Tomotaka Ohira, Noriko Tsuchiya, Sono Nishizawa, Tomoyuki Koya, Tatsuro Egawa, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka   +12 more
doaj   +1 more source

HEAT STRESS IN RUMINANTS

, 2017
Heat stress is one of the most important environmental stressors that reduce productivity in animal breeding. The productivity of farm animals is significantly reduced due to temperature increases. As a result, significant economic losses occur during the summer months.
Sireli, Halit Deniz, Tutkun, Muhittin, Tatar, Ali Murat, Tuncer, Selcuk Seckin   +3 more
openaire   +3 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Comparison of heat-shock responses between the hydrothermal vent shrimp Rimicaris exoculata and the related coastal shrimp Palaemonetes varians [PDF]

, 2010
The deep-sea vent shrimp Rimicaris exoculata is believed to occur at the hot end of the hydrothermal biotope in order to provide essential elements to its epibiosis. Because it is found close to hot venting water, R.
Thomas Chertemps, Sven Thatje, Shillito, Bruce, Leger, Nelly, Bruce Shillito, Nelly Léger, Chertemps, Thomas, Thatje, Sven, Ravaux, Juliette, Delphine Cottin, Cottin, Delphine, Juliette Ravaux   +11 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Interaction of Aflatoxicosis with Heat Stress ,

Poultry Science, 1975
An earlier study reported an increased resistance of chickens to an acute lethal heating episode (43 degrees C. and 45% relative humidity) during aflatoxicosis. This varies from other stresses investigated which interact with aflatoxicosis to make chickens more sensitive to the stress factor.
R D, Wyatt, P, Thaxton, P B, Hamilton
openaire   +2 more sources

THI APPLICATION TO INSURING AGAINST HEAT STRESS IN DAIRY COWS [PDF]

Heat stress is associated with reduced milk production in dairy cows. Insurance instruments based on an index of ambient temperature and relative humidity measured at Macon, Georgia and Tallahassee, Florida are shown to reduce net revenue risk for a ...
Deng, Xiaohui, Barnett, Barry J., West, Joe W., Vedenov, Dmitry V.   +3 more
core