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Journal of Intensive Care, 2018 Background Heat stroke is a life-threatening injury requiring neurocritical care; however, heat stroke has not been completely examined due to several possible reasons, such as no universally accepted definition or classification, and the occurrence of ...
Toru Hifumi +3 more
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Exertional heat stroke: pathophysiology and risk factors
BMJ Medicine, 2022 Exertional heat stroke, the third leading cause of mortality in athletes during physical activity, is the most severe manifestation of exertional heat illnesses. Exertional heat stroke is characterised by central nervous system dysfunction in people with
Christian K Garcia +4 more
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Journal of Neuroinflammation, 2021 Background Patients with prior illness are more vulnerable to heat stroke-induced injury, but the underlying mechanism is unknown. Recent studies suggested that NLRP3 inflammasome played an important role in the pathophysiology of heat stroke. Methods In
Zi-Teng Zhang +10 more
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GeoHealth, 2022 Heat stroke is a serious heat‐related health outcome that can eventually lead to death. Due to the poor accessibility of heat stroke data, the large‐scale relationship between heat stroke and meteorological factors is still unclear.
Qinmei Han +5 more
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Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Frontiers in Neurology, 2021 We here provide an overview of the pathophysiological mechanisms during heat stroke and describe similar mechanisms found in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Dominic Stanculescu +5 more
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A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke [PDF]
Nature Communications, 2021 Mutations in the type 1 ryanodine receptor (RyR1), a Ca2+ release channel in skeletal muscle, hyperactivate the channel to cause malignant hyperthermia (MH) and are implicated in severe heat stroke.
Toshiko Yamazawa +25 more
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The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury [PDF]
Frontiers in Cell and Developmental BiologyHeat stroke is a severe and life-threatening condition characterized by elevated core body temperature and central nervous system dysfunction, often accompanied by multi-organ damage.
Shaokang Wang +5 more
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Severe heat stroke complicated by multiple cerebral infarctions: a case report [PDF]
Journal of Medical Case Reports, 2021 Background Heat-related illnesses include symptoms such as heat syncope/cramps, heat exhaustion, and life-threatening heat stroke. Usually, a heat stroke causes cerebellar ataxia, cognitive impairment, dysphagia, and aphasia.
Ryo Kamidani +19 more
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Military Medical Research, 2020 Heat stroke is the most severe type of heat illness, it is often accompanied by severe multiorgan damage and has a high fatality rate. In January 2020, based on new research evidence and the experiences of Chinese experts in heat stroke, the Expert Group
Shu-Yuan Liu +6 more
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Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironment [PDF]
BMC Medical GenomicsBackground Heat stroke, caused by excessive heat production or impaired dissipation, often results from prolonged heat exposure or strenuous activity. Ferroptosis, a novel form of programmed cell death, has been implicated in its pathogenesis, though its
Defeng Yin +9 more
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