Results 41 to 50 of about 2,047,625 (245)

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Successful Heat Stroke-Induced Pediatric Acute Liver Failure Treatment With N-Acetylcysteine Case Report

Critical Care Explorations
BACKGROUND:. Previously healthy children are at risk of developing exertional heat stroke when experiencing extreme heat. Pediatric clinicians in primary care, emergency department, and critical care settings should be versed in the management of ...
Archana Anandakrishnan, DO, Amanda O’Halloran, MD, MSHP, Tamir Diamond, MD, MSTR   +2 more
doaj   +1 more source

Influence of the coronavirus disease 2019 (COVID‐19) pandemic on the incidence of heat stroke and heat exhaustion in Japan: a nationwide observational study based on the Heatstroke STUDY 2019 (without COVID‐19) and 2020 (with COVID‐19)

Acute Medicine & Surgery, 2022
Aim To assess heat stroke and heat exhaustion occurrence and response during the coronavirus disease 2019 pandemic in Japan. Methods This retrospective, multicenter, registry‐based study describes and compares the characteristics of patients between the ...
Jun Kanda, Yasufumi Miyake, Tadashi Umehara, Shoichi Yoshiike, Motoki Fujita, Kei Hayashida, Toru Hifumi, Hitoshi Kaneko, Tatsuho Kobayashi, Yutaka Kondo, Takashi Moriya, Yohei Okada, Yuichi Okano, Junya Shimazaki, Shuhei Takauji, Junko Yamaguchi, Masaharu Yagi, Hiroyuki Yokota, Keiki Shimizu, Arino Yaguchi, Shoji Yokobori   +20 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Heat stroke: knowledge and practices of medical professionals in pediatric emergency medicine departments – a survey study

Israel Journal of Health Policy Research, 2021
Background and importance Heat stroke is a life-threatening condition affecting children worldwide. Rapid cooling remains the most important feature of emergency management.
Noy Cohen-Ronen, Ayelet Rimon, Neta Cohen, Tali Capua   +3 more
doaj   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Heat stress [PDF]

"Heat stress, from exertion or hot environments, places workers at risk for illnesses such as heat stroke, heat exhaustion, or heat cramps." - NIOSHTIC-2NIOSHTIC No 20036814CDC-INFO Pub ID ...

core   +1 more source

Stroke outcome in clinical trial patients deriving from different countries [PDF]

, 2008
<p><b>Background and Purpose:</b> Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across ...
Lyden, Patrick, Sacco, R.L., Atula, Sari, Lees, Kennedy R, Hacke, Werner, Marler, J.R., Marler, John R., Lees, K.R., Grotta, James, Sacco, Ralph L, Bath, Philip M W, Lyden, Patrick D., Sacco, Ralph, Grotta, J., Sacco, Ralph L., Lees, Kennedy R., Bath, Philip M.W., Bath, P.M.W., Ali, M., Ali, Myzoon, Lyden, P., Marler, John, Hacke, W., Grotta,, James, Marler, John R, Atula, S., Ali, Myzoon; id_orcid   +26 more
core   +1 more source