Results 81 to 90 of about 2,321,244 (303)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Study on properties of composites reinforced by heat treated glass fibres simulating thermal recycling conditions [PDF]
, 2013 In the present study, commercial chopped glass fibres were heat treated at 300°C, 450°C, 500°C and 600°C to imitate a composite thermal recycling process.
Kao, Chih-Chuan +2 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Carbon footprint analysis of wastewater treatment processes coupled with sludge in situ reduction
Water Research XThe goal of this study was to assess the impacts or benefits of sludge in situ reduction (SIR) within wastewater treatment processes with relation to global warming potential in wastewater treatment plants, with a comprehensive consideration of ...
Yiyue Sun +9 more
doaj +1 more source
Electro-hyperthermia in Oncology [PDF]
, 2001 Hyperthermia is a rapidly developing treatment method in oncology. The classical effect is based on well-focused energy absorption targeting the malignant tissue.
Szász, András +2 more
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Ti–6Al–4V alloy prepared by laser powder bed fusion of a coarse powder
Heat Treatment and Surface EngineeringA Ti–6Al–4V (wt%) alloy was prepared by laser powder bed fusion (LPBF) of a coarse powder with particle sizes in the range of 50–200 μm. The effect of volume energy density (VED) on cavities/pores, microstructure and mechanical properties of the LPBF ...
Mengmeng Zhang +4 more
doaj +1 more source
Effect of heat treatment on stiffness and damping of SiC/Ti-15-3 [PDF]
The effect of heat treatment on material properties of SiC/Ti-15-3 was measured by vibration tests. Heat treatment changes the microstructure, which was found to stiffen the matrix and reduce its damping capacity.
Grady, Joseph E., Lerch, Bradley A.
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Microstructural evolution in 12% Cr heat-resistant steel during compression deformation at 650°C
Heat Treatment and Surface EngineeringThe 12% Cr heat-resistant steel used for critical components of fossil-fired power plants works in high-temperature and high-pressure steam environments for a long time and inevitably undergoes a certain amount of plastic deformation during service. This
Xin You +4 more
doaj +1 more source