Results 91 to 100 of about 1,032,407 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Heat treatment for insect control : developments and applications / [PDF]

Stored product insects and other pests represent a major hygiene and safety issue to many industries, from food production to building infestation, and issues for timber pallets and packaging.
Hammond, David,author.
core  

Review of computational bio-heat transfer modeling for tumour treatment [PDF]

, 2008
One of the effective aggressive treatments of tumours is to elevate its temperature in a controlled manner giving rise to cell apoptosis and tissue necrosis.
Aouf, Rashad (R13879), Vojislav Ilic, Steve Hansen, Hansen, Stephen (R7769), Ilic, Vojislav (R7891), Rashad Aouf   +5 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Influence of Hot Deformation Temperature on Grain Size and γ′ Phase in U720Li Alloy After Sub-Solvus Heat Treatment [PDF]

Precise control of forging and heat treatment parameters is essential to achieve microstructural homogeneity in turbine disks, ensuring optimal mechanical performance for aerospace applications.
Junyi Cheng, Lei Xiao, Jiangying Xiong, Jianzheng Guo, Ganjiang Feng, Anping Long, Xiangdong Ma   +6 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Diffusion-driven L10 FePt phase formation in Fe/Ag(Au)/Pt and Pt/Ag(Au)/Fe trilayers with inverted layer stacking

Results in Surfaces and Interfaces
In this work the diffusion-induced formation of an ordered L10 FePt phase in Fe(15 nm)/Ag(Au)(10 nm)/Pt(15 nm) and Pt(15 nm)/Ag(Au)/Fe(15 nm) trilayers with a Ag(Au) interlayer upon annealing is studied. The films were prepared by magnetron sputtering on
G.L. Katona, P.V. Makushko, N.Y. Schmidt, O. Lik, T.I. Verbytska, G. Beddies, D.L. Beke, M. Albrecht, Yu.M. Makogon   +8 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Carbon footprint analysis of wastewater treatment processes coupled with sludge in situ reduction

Water Research X
The goal of this study was to assess the impacts or benefits of sludge in situ reduction (SIR) within wastewater treatment processes with relation to global warming potential in wastewater treatment plants, with a comprehensive consideration of ...
Yiyue Sun, Yi Zuo, Yanjun Shao, Lihua Wang, Lu-Man Jiang, Jiaming Hu, Chuanting Zhou, Xi Lu, Song Huang, Zhen Zhou   +9 more
doaj   +1 more source