Results 91 to 100 of about 1,088,008 (363)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Investigation of the Heat Treatment Process and Formation Mechanism of Grain Boundary Serration for GH4795 Superalloy

, 2022
Heat treatments, including solution treatment and isothermal heat treatment, were conducted to investigate the grain boundary serration of GH4975 superalloy.
Hao Yu, Bingchao Xie, Wenyun Zhang, Yongquan Ning, Shuo Huang, Beijiang Zhang   +5 more
core   +1 more source

Microstructural evolution in 12% Cr heat-resistant steel during compression deformation at 650°C

Heat Treatment and Surface Engineering
The 12% Cr heat-resistant steel used for critical components of fossil-fired power plants works in high-temperature and high-pressure steam environments for a long time and inevitably undergoes a certain amount of plastic deformation during service. This
Xin You, Yuantao Xu, Kaihao Guo, Chenghui Xia, Xuejun Jin   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Impact of Heat Treatment on Microstructure Evolution in Grey Cast Iron EN-GJL-300

This work investigated changes in the microstructure and local mechanical properties after the application of selected heat treatments to EN-GJL-300 grey cast iron.
Martin Bilka, Jozef Majerík, Michal Krbata, Marcel Kohutiar, Ingrid Kovaříková, Peter Petruš, Igor Barényi   +6 more
core   +1 more source

Real-time prediction method of carbon concentration in carburized steel based on a BP neural network

Heat Treatment and Surface Engineering
Gears are key components of mechanical transmission systems. They need to be carburized and quenched to meet the requirements of internal toughness and external hardness, to obtain higher hardness and wear resistance.
Zhang Yingtao, Tang Zirong, He Lei, Mohammad Hadi Mahdipanah, Wang Yanjie   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Phase Formation and Stabilization Behavior of Ca-PSZ by Post-Heat Treatment

, 2022
The phase formation and stabilization behaviors of calcia partially stabilized zirconia (Ca-PSZ) were investigated with regard to the CaO content and post-heat treatment.
Ilguk Jo, Kanghee Jo, Heesoo Lee, Juyoung Kim, Hyunjo Yoo, Hwanseok Lee   +5 more
core   +1 more source

Effects of annealing powder on microstructures and tensile properties of LPBF-processed Haynes230 superalloy

Heat Treatment and Surface Engineering
This study reveals a novel understanding of the influence of annealing the feed powder, which alters the precipitate characteristics in the powder particles on the microstructure and mechanical properties of Haynes230 superalloy fabricated by laser ...
Qianhao Zhang, Wei Zeng, Tian Xia, Deliang Zhang   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source