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Heavy Chains, Heavy Consequences: A Case of Concomitant Heavy Chain Amyloidosis and Heavy Chain Deposition Disease. [PDF]

Kidney Med
Amoh BK, Ghanem G, Zuckerman JE, Bruss Z, Chuang K.   +4 more
europepmc   +3 more sources

Heavy Chain Disease [PDF]

Definitions, 2020
Department of Hematology Medical Oncology and In 1963 and 1964, Franklin1'2 reported the first case of a rare disorder of immunoglobulin metabolism characterized clinically by a generalized lymphadenopathy, recurrent respiratory infections ...
William, M., Murphy, Sharad, D., Deodhar
semanticscholar   +4 more sources

Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis.

PLoS Genetics, 2019
The interplay between signalling pathways and metabolism is crucial for tissue growth. Yet, it remains poorly understood. Here, we studied the consequences of modulating iron metabolism on the growth of Drosophila imaginal discs.
Simone Mumbauer, Justine Pascual, Irina Kolotuev, Fisun Hamaratoglu   +3 more
doaj   +2 more sources

Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines

Vaccines, 2022
Leukocyte cell-surface HLA-I molecules, involved in antigen presentation of peptides to CD8+ T-cells, consist of a heavy chain (HC) non-covalently linked to β2-microglobulin (β2m) (Face-1).
Mepur H. Ravindranath, Narendranath M. Ravindranath, Senthamil R. Selvan, Edward J. Filippone, Carly J. Amato-Menker, Fatiha El Hilali   +5 more
doaj   +1 more source

Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients

Antibodies, 2022
Serum anti-HLA-I IgG are present in non-alloimmunized males, cancer patients, and transplant recipients. Anti-HLA-I antibodies are also present in intravenous immunoglobulin (IVIg), prepared from the plasma of thousands of healthy donors.
Mepur H. Ravindranath, Narendranath M. Ravindranath, Fatiha El Hilali, Senthamil R. Selvan, Edward J. Filippone   +4 more
doaj   +1 more source

Heavy Metal Induced Oxidative Stress Mitigation and ROS Scavenging in Plants

Plants, 2023
Although trace elements are essential for life, environmental contamination due to metal accumulation and overuse in various sectors, such as healthcare, agriculture, industry, and cosmetics, poses significant health concerns. Exposure of plants to heavy
Sheikh Mansoor, Asif Ali, Navneet Kour, J. Bornhorst, K. Alharbi, J. Rinklebe, Diaa Abd El Moneim, P. Ahmad, Y. Chung   +8 more
semanticscholar   +1 more source

Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age

Frontiers in Immunology, 2020
B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied.
Marie Ghraichy, Marie Ghraichy, Jacob D. Galson, Jacob D. Galson, Aleksandr Kovaltsuk, Valentin von Niederhäusern, Valentin von Niederhäusern, Jana Pachlopnik Schmid, Jana Pachlopnik Schmid, Mike Recher, Annaïse J. Jauch, Enkelejda Miho, Enkelejda Miho, Enkelejda Miho, Dominic F. Kelly, Dominic F. Kelly, Charlotte M. Deane, Johannes Trück, Johannes Trück   +18 more
doaj   +1 more source

Immune subtraction for improved resolution in serum protein immunofixation electrophoresis and antibody isotype determination in a patient with autoantibody

Practical Laboratory Medicine, 2021
Heavy chain isotypes of low level monoclonal immunoglobulins are sometimes obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins.
Asad Ullah, Nivin Omar, Natasha M. Savage, Roni J. Bollag, Gurmukh Singh   +4 more
doaj   +1 more source

The validation of artificial anti‐monkeypox antibodies by in silico and experimental approaches

Immunity, Inflammation and Disease, 2023
As a result of smallpox immunization programs that ended more than 40 years ago, a significant portion of the world's population is not immune. Moreover, due to the lack of anti‐monkeypox drugs and vaccines against monkeypox, the spread of this virus may
Sadeq Shabani, Mohsen Rashidi, Shakila Radgoudarzi, Ali Jebali   +3 more
doaj   +1 more source

Mu heavy chain disease with MYD88 L265P mutation: an unusual manifestation of lymphoplasmacytic lymphoma

Diagnostic Pathology, 2022
Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda, Sarah E. Wheeler, David L. Murray, Mindy C. Kohlhagen, Jeffrey A. VosUPMC, Svetlana A. Yatsenko, Mounzer E. Agha, Miroslav Djokic, Steven H. Swerdlow, Nathanael G. Bailey   +9 more
doaj   +1 more source