Results 101 to 110 of about 398,844 (320)

Ergodicity of Markov chain Monte Carlo with reversible proposal [PDF]

open access: yesarXiv, 2016
We describe ergodic properties of some Metropolis-Hastings (MH) algorithms for heavy-tailed target distributions. The analysis usually falls into sub-geometric ergodicity framework but we prove that the mixed preconditioned Crank-Nicolson (MpCN) algorithm has geometric ergodicity even for heavy-tailed target distributions.
arxiv  

MYH11 (myosin heavy chain) [PDF]

open access: yesAtlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on MYH11 (myosin heavy chain), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

open access: yesAdvanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang   +6 more
wiley   +1 more source

The two subset recurrent property of Markov chains [PDF]

open access: yesarXiv, 2016
This paper proposes a new type of recurrence where we divide the Markov chains into intervals that start when the chain enters into a subset A, then sample another subset B far away from A and end when the chain again return to A. The length of these intervals have the same distribution and if A and B are far apart, almost independent of each other.
arxiv  

Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

open access: yesAdvanced Biology, EarlyView.
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André   +3 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

open access: yesAdvanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang   +5 more
wiley   +1 more source

Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells

open access: yesmAbs, 2019
Multiple strategies have been developed to facilitate the efficient production of bispecific IgG (BsIgG) in single host cells. For example, we previously demonstrated near quantitative (≥90%) formation of BsIgG of different species and isotypes by ...
Kamal Kishore Joshi   +6 more
doaj   +1 more source

On generic chaining and the smallest singular value of random matrices with heavy tails [PDF]

open access: yesarXiv, 2011
We present a very general chaining method which allows one to control the supremum of the empirical process $\sup_{h \in H} |N^{-1}\sum_{i=1}^N h^2(X_i)-\E h^2|$ in rather general situations. We use this method to establish two main results. First, a quantitative (non asymptotic) version of the classical Bai-Yin Theorem on the singular values of a ...
arxiv  

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