Results 101 to 110 of about 1,211,483 (357)

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Nature Communications, 2019
Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin ...
Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise   +13 more
doaj   +1 more source

Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement [PDF]

, 2017
The current model for vesicular traffic to and from the plasma membrane is accepted but the molecular requirements for this coordination are not well defined.
Blatt, Michael R., Larson, Emily R., Marion-Poll, Annie, Roux, Camille, Van Zelm, Eva   +4 more
core   +2 more sources

ICU‐EEG Pattern Detection by a Convolutional Neural Network

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients in the intensive care unit (ICU) often require continuous EEG (cEEG) monitoring due to the high risk of seizures and rhythmic and periodic patterns (RPPs). However, interpreting cEEG in real time is resource‐intensive and heavily relies on specialized expertise, which is not always available.
Giulio Degano, Hervé Quintard, Andreas Kleinschmidt, Nikita Francini, Oana E. Sarbu, Pia De Stefano   +5 more
wiley   +1 more source

Surfactant-assisted liquefaction of particulate carbonaceous substances [PDF]

, 1978
A slurry of carbonaceous particles such as coal containing an oil soluble polar substituted oleophilic surfactant, suitably an amine substituted long chain hydrocarbon, is liquefied at high temperature and high hydrogen presence.
Hsu, G. C.
core   +1 more source

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han, Brooke A. Keating, Brian S. Gloss, Xianzhong Lau, Ruwani Dissanayake, Hiroya Nishida, Jessica Hayes, Shrujna Patel, Shekeeb S. Mohammad, Russell C. Dale   +9 more
wiley   +1 more source

Functional material features of Bombyx mori silk light versus heavy chain proteins [PDF]

, 2015
Bombyx mori (BM) silk fibroin is composed of two different subunits; heavy chain and light chain fibroin linked by a covalent disulphide bond. Current methods of separating the two silk fractions is complicated and produces inadequate quantities of the ...
Agarwal N., Ahmad A., Altman G. H., Benjamin Hanby, Carole C. Perry, Chen C., Chen Z., Creighton T. E., Damrongrungruang T., David J. Belton, David L. Kaplan, Dewair M., Foo C. W., Garel J., Gellynck K., Ha S. W., Hardy J. G., Holland C., Inoue S., Jin H. J., Kim H. J., Kim K., Kodama K., Kojima K., Li A., Li W., Mita K., Mondal M., Mori K., Muhammad S. Zafar, Nair L. S., Numata K., Omenetto F. G., Oyama F., Panilaitis B., Peh R. F., Rammensee S., Shimura K., Swank R. T., Taddei P., Takagi T., Takasu Y., Takei F., Tanaka K., Tanaka K., Wadbua P., Wang Y., Wenk E., Wray L. S., Yamaguchi K., Zhang Y., Zhang Y., Zhang Y., Zhou C., Zuo B.   +54 more
core   +1 more source

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich, Tilman Schneider‐Hohendorf, Eric Baetscher, Evan L. Riddle, Marie Deffner, Emily Katsnelson, Janine Ferrant‐Orgettas, Julie Czerkowicz, John Anderson, Susan E. Goelz, Nicholas Schwab   +10 more
wiley   +1 more source

Depletion of Branched-Chain Aminotransferase 2 (BCAT2) Enzyme Impairs Myoblast 3 Survival and Myotube Formation [PDF]

, 2019
Much is known about the positive effects of branched-chain amino acids (BCAA) in regulating muscle protein metabolism. Comparatively much less is known about the effects of these amino acids and their metabolites in regulating myotube formation.
ADEGOKE, OLASUNKANMI, Dhanani, Zameer N., Mann, Gagandeep   +2 more
core  

New limits on heavy sterile neutrino mixing in ${^{8}\rm{B}}$-decay obtained with the Borexino detector

, 2013
If heavy neutrinos with mass $m_{\nu_{H}}\geq$2$ m_e $ are produced in the Sun via the decay ${^8\rm{B}} \rightarrow {^8\rm{Be}} + e^+ + \nu_H$ in a side branch of pp-chain, they would undergo the observable decay into an electron, a positron and a light
Avanzini, M. Buizza, Bellini, G., Benziger, J., Bick, D., Bonfini, G., Borexino collaboration, Bravo, D., Caccianiga, B., Cadonati, L., Calaprice, F., Cavalcante, P., Chavarria, A., Chepurnov, A., DAngelo, D., Davini, S., Derbin, A., Drachnev, I., Empl, A., Etenko, A., Fomenko, K., Franco, D., Galbiati, C., Gazzana, S., Ghiano, C., Giammarchi, M., Goger-Neff, M., Goretti, A., Grandi, L., Hagner, C., Hungerford, E., Ianni, Aldo, Ianni, Andrea, Kobychev, V., Korablev, D., Korga, G., Kryn, D., Laubenstein, M., Lewke, T., Litvinovich, E., Loer, B., Lombardi, F., Lombardi, P., Ludhova, L., Lukyanchenko, G., Machulin, I., Manecki, S., Maneschg, W., Manuzio, G., Meindl, Q., Meroni, E., Miramonti, L., Misiaszek, M., Mosteiro, P., Muratova, V., Oberauer, L., Obolensky, M., Ortica, F., Otis, K., Pallavicini, M., Papp, L., Perasso, L., Perasso, S., Pocar, A., Ranucci, G., Razeto, A., Re, A., Romani, A., Rossi, N., Saldanha, R., Salvo, C., Schonert, S., Simgen, H., Skorokhvatov, M., Smirnov, O., Sotnikov, A., Sukhotin, S., Suvorov, Y., Tartaglia, R., Testera, G., Vignaud, D., Vogelaar, R. B., von Feilitzsch, F., Winter, J., Wojcik, M., Wright, A., Wurm, M., Xu, J., Zaimidoroga, O., Zavatarelli, S., Zuzel, G.   +89 more
core   +3 more sources