IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications [PDF]
, 2019 The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples ...
Amato, Teresa +15 more
core +2 more sources
Fibre types in skeletal muscles of chronic obstructive pulmonary disease patients related to respiratory function and exercise tolerance. [PDF]
, 1997 This study aimed to investigate the relationship between skeletal muscle, fibre type composition, functional respiratory impairment and exercise tolerance in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
Bottinelli, R +7 more
core +1 more source
Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKC subversion induces up-regulation of PKC II expression in B lymphocytes [PDF]
, 2015 Overwhelming evidence identifies the microenvironment as a critical factor in the development and progression of chronic lymphocytic leukemia, underlining the importance of developing suitable translational models to study the pathogenesis of the disease.
Cosimo, Emilio +10 more
core +3 more sources
Moyamoya-like cerebrovascular disease in a child with a novel mutation in myosin heavy chain 11 [PDF]
, 2017 Heterozygous mutations in the MYH11 gene affecting the C-terminal coiled-coil region of the smooth muscle myosin heavy chain, a contractile protein of smooth muscle cells (SMC), have been described to cause thoracic aortic aneurysm or aortic dissection ...
Brogan, P +8 more
core +1 more source
Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]
, 2009 Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Antoni L. Andreu +8 more
core +12 more sources
Comparison of Hevylite™ IgA and IgG assay with conventional techniques for the diagnosis and follow-up of plasma cell dyscrasia [PDF]
, 2015 Background: Heavy/light chain assay allows the characterization and quantification of immunoglobulin light chains bound to heavy chains for each Ig’k and Ig’ immunoglobulin class, discriminating between the involved/uninvolved isotypes in plasma cell ...
Caimi, Luigi +6 more
core +1 more source
Machine Learning for Infectious Disease Risk Prediction: A Survey [PDF]
arXiv, 2023 Infectious diseases, either emerging or long-lasting, place numerous people at risk and bring heavy public health burdens worldwide. In the process against infectious diseases, predicting the epidemic risk by modeling the disease transmission plays an essential role in assisting with preventing and controlling disease transmission in a more effective ...
arxiv
Are papers addressing certain diseases perceived where these diseases are prevalent? The proposal to use Twitter data as social-spatial sensors [PDF]
, 2020 We propose to use Twitter data as social-spatial sensors. This study deals with the question whether research papers on certain diseases are perceived by people in regions (worldwide) that are especially concerned by the diseases. Since (some) Twitter data contain location information, it is possible to spatially map the activity of Twitter users ...
arxiv +1 more source
Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells In Vivo [PDF]
, 2018 Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Keppler, SJ +10 more
core +1 more source
AI-Based Decadal Predictive Analysis of Twenty Infectious Diseases in China with an Improved BSTS-MCMC Model [PDF]
arXiv, 2023 This study embarks on a comprehensive exploration of the decadal trends and future trajectories of twenty distinct infectious diseases in China from 1998 to 2021. A refined Hybrid Bayesian Structural Time Series (BSTS)-Markov Chain Monte Carlo (MCMC) model is employed, intertwining with Long Short-Term Memory (LSTM) networks to dissect intricate ...
arxiv