Two Cases of γ-Heavy Chain Disease and a Review of the Literature [PDF]
Case Reports in Hematology, 2018 Gamma heavy chain disease (γ-HCD) is a rare lymphoproliferative disorder characterised by the production of a truncated immunoglobulin heavy chain. Fewer than 200 cases have been reported in the literature. In some cases, γ-HCD occurs with other lymphoid
I. Ramasamy, Z. Rudzki
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Gamma heavy chain disease associated with T-cell large granular lymphocyte lymphoproliferative disorder: case report and literature review. [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2023 Heavy chain diseases are rare B-cell neoplasms consisting of the production of a monoclonal immunoglobulin composed of the only heavy chain without corresponding light chains.
Maria Laura Bisegna +5 more
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Mu heavy chain disease with MYD88 L265P mutation: an unusual manifestation of lymphoplasmacytic lymphoma [PDF]
Diagnostic Pathology, 2022 Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda +9 more
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Gamma heavy chain disease associated with rheumatoid arthritis: a case report [PDF]
Journal of Medical Case Reports, 2021 Background Gamma heavy chain disease (γ-HCD) is a monoclonal gammopathy defined by an abnormal clonal and isolated production of incomplete heavy chain gamma (γ), unable to bind with light chains kappa or lambda.
Gwenvaël Danic +5 more
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Immunoglobulin heavy chain gene rearrangement in heavy chain deposition disease suggests it is a plasma cell disease: a case report [PDF]
Journal of International Medical Research, 2022 Heavy chain deposition disease (HCDD) is characterized by the deposition of truncated monoclonal immunoglobulin heavy chains along glomerular basement membranes.
Qingqing Rao, Ricong Xu, Qijun Wan
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Gamma heavy chain disease: a retrospective analysis of 6 cases [PDF]
Orphanet Journal of Rare Diseases, 2023 Long Chang, Dao-bin Zhou, Xin-xin Cao
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Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes
Haematologica, 2012 Background Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic ...
Simone Ferrero +24 more
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Light chain proteinuria revealing mu-heavy chain disease: an atypical presentation of Waldenström macroglobulinemia in two cases [PDF]
Haematologica, 2021 Hélène Vergneault +9 more
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New England Journal of Medicine, 1968 Abstract In a seventh patient with heavy-chain disease the clinical findings were those of a malignant lymphoma without skeletal involvement. The patient's serum and urine contained an M component with electrophoretic, antigenic and ultracentrifugal properties resembling those of the Fc fragment of γG globulin.
Leonard Ellman, Kurt J. Bloch
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Gamma heavy chain disease complicated by pulmonary hypertension, which was successfully treated with lenalidomide. [PDF]
BMJ Case Rep, 2020 Shibata S, Fukunaga A.
europepmc +3 more sources