Results 31 to 40 of about 172,377 (268)

Heavy-Ion Accelerators

Annual Review of Nuclear Science, 1961
A review is presented of aspects of heavy-ion acceleration, including ion sources, electron stripping, types of accelerators (e,g., d-c high-voltage accelerators, cyclotrons, and linear accelerators), and possibilities for increasing currents and energies. A bibliography containing 68 references is included. (T.F.H.)
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The preliminary results of proton and carbon ion therapy for chordoma and chondrosarcoma of the skull base and cervical spine

Radiation Oncology, 2019
Purpose To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiation therapy.
Xiyin Guan, Jing Gao, Jiyi Hu, Weixu Hu, Jing Yang, Xianxin Qiu, Chaosu Hu, Lin Kong, Jiade J. Lu   +8 more
doaj   +1 more source

Particle Beam Radiation Therapy for Skull Base Sarcomas

Frontiers in Oncology, 2020
Background: To report the clinical experience of carbon-ion and proton radiation therapy for skull base sarcomas.Methods: An analysis of the retrospective data registry from the Shanghai Proton and Heavy Ion Center for patients with skull base sarcomas ...
Jing Yang, Jing Yang, Weixu Hu, Weixu Hu, Xiyin Guan, Xiyin Guan, Jiyi Hu, Jiyi Hu, Jing Gao, Jing Gao, Xianxin Qiu, Xianxin Qiu, Qingting Huang, Qingting Huang, Wenna Zhang, Wenna Zhang, Lin Kong, Lin Kong, Lin Kong, Jiade J. Lu, Jiade J. Lu   +20 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Dose–Volume Constraints for Thoracic, Abdominal, and Pelvic Carbon Ion Radiotherapy: A Literature Review

Cancer Medicine
Background Applying dose–volume constraints is extremely important in ensuring the safe use of radiotherapy. However, constraints for carbon ion radiotherapy (CIRT) have not been established yet.
Maria Varnava, Mutsumi Tashiro, Masahiko Okamoto, Ken Ando, Nobutero Kubo, Hidemasa Kawamura, Masahiro Onishi, Kei Shibuya, Takuya Kumazawa, Takeru Ohtaka, Tatsuya Ohno   +10 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Carbon ion radiotherapy boost in the treatment of glioblastoma: a randomized phase I/III clinical trial

Cancer Communications, 2019
Background Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival 
Lin Kong, Jing Gao, Jiyi Hu, Rong Lu, Jing Yang, Xianxin Qiu, Weixu Hu, Jiade J. Lu   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Particle Beam Radiation Therapy for Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses

Frontiers in Oncology, 2020
Background: Sinonasal adenoid cystic carcinoma (SNACC) presents a challenge to oncologists due to its complex anatomy and poor prognosis. Although radiation therapy, either definitive or adjuvant to surgery, is an important part of the multidisciplinary ...
Weixu Hu, Weixu Hu, Jiyi Hu, Jiyi Hu, Qingting Huang, Qingting Huang, Jing Gao, Jing Gao, Jing Yang, Jing Yang, Xianxin Qiu, Xianxin Qiu, Lin Kong, Lin Kong, Jiade J. Lu, Jiade J. Lu   +15 more
doaj   +1 more source