Results 51 to 60 of about 171,650 (268)
Chinese Journal of Cancer, 2016 Background After definitive chemoradiotherapy for non-metastatic nasopharyngeal carcinoma (NPC), more than 10% of patients will experience a local recurrence. Salvage treatments present significant challenges for locally recurrent NPC.
Lin Kong +6 more
doaj +1 more source
Frontiers in Oncology, 2020 Recently, a growing number of studies focus on partial tumor irradiation to induce the stronger non-target effects. However, the value of partial volume carbon ion radiotherapy (CIRT) targeting hypoxic region of a tumor under imaging guidance as well as ...
Qingting Huang +17 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Heavy Ion Physics at the LHC [PDF]
Nuclear Physics A, 2005 The ion-ion center of mass energies at the LHC will exceed that at RHIC by nearly a factor of 30, providing exciting opportunities for addressing unique physics issues in a completely new energy domain. Some highlights of this new physics domain are presented here. We briefly describe how these collisions will provide new insights into the high density,
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Annual Review of Nuclear Science, 1961 A review is presented of aspects of heavy-ion acceleration, including ion sources, electron stripping, types of accelerators (e,g., d-c high-voltage accelerators, cyclotrons, and linear accelerators), and possibilities for increasing currents and energies. A bibliography containing 68 references is included. (T.F.H.)
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Multistrangeness in heavy-ion collisions [PDF]
Proceedings of XXII International Baldin Seminar on High Energy Physics Problems — PoS(Baldin ISHEPP XXII), 2015 We discuss strangeness production in heavy-ion collisions in the broad energy range --- from SIS energies through AGS-SPS-RHIC and upto LHC energies. On several examples we demonstrate how the strange particle production can reveal information about the collision dynamics and about possible modifications of particle properties in medium.
Kolomeitsev, E. E. +3 more
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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Jets in Heavy Ion Collisions [PDF]
Nuclear Physics A, 2007 4 pages, 3 postscript figures. Contributed to 38th Rencontres de Moriond on QCD and Hadronic Interactions, Les Arcs, France, 22-29 Mar ...
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