Results 131 to 140 of about 101,813 (256)

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Let's Talk About Bone Cylinders. Taphonomy of Carnivores and Humans

International Journal of Osteoarchaeology, EarlyView.
ABSTRACTBone cylinders are a distinctive structure predominantly produced by durophagous carnivoran species during the consumption of long bones, in which the diaphyseal canal remains intact while both epiphyses are removed or consumed. This study evaluates the significance of this morphology, traditionally attributed to extant and extinct hyena ...
Darío Herranz‐Rodrigo
wiley   +1 more source

Mechanisms and impacts of future plant invasions: research agendas and management needs under disruptive social‐ecological change scenarios

Oikos, EarlyView.
No‐analogue futures are characteristic of the Anthropocene, but how global change, and societies' responses, will affect plant invasions remains unclear. Conducting research now to address future needs is crucial for guiding invasion management and policy.
Jennifer L. Bufford, Angela J. Brandt, Rowan Sprague, Christopher E. Buddenhagen, Richard P. Duncan, Nichola Harcourt, Philip E. Hulme, Hao Ran Lai, Kate G. McAlpine, Chris McGrannachan, Fiona J. Thomson, Vincent van Uitregt, Duane A. Peltzer   +12 more
wiley   +1 more source

Human–wildlife coexistence and social context: Evidence from farmer communities in southern Sri Lanka

People and Nature, EarlyView.
Abstract Studies on human–wildlife interactions (HWI) often focus on conflict mitigation studies, thus overlooking underlying factors that influence community decisions to coexist with wildlife. To address this knowledge gap, we collected empirical evidence of how community interactions with wildlife are shaped by their social contexts.
Anuradhi Dulangi Jayasinghe, Georgette Leah Burns, Johanna Nalau, Duan Biggs   +3 more
wiley   +1 more source

Hedgehog signalling in rheumatoid arthritis

, 2008
Rheumatoide Arthritis ist eine chronische, degenerative Autoimmunkrankheit, die sich insbesondere durch die Persistenz einer Entzündungsreaktion im Gelenk und der Bildung eines Pannusgewebes auszeichnet. Zellen des Immunsystems und synoviale Fibroblasten
Gorka, Oliver
core  

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

A Systematic Review of Participatory Science Approaches in K–12 Ecological Monitoring

Science Education, EarlyView.
ABSTRACT Participatory science has emerged as a vital educational approach for engaging K–12 learners in authentic scientific inquiry while generating data for ecological monitoring. This systematic review synthesizes 72 empirical studies published between 2006 and 2025 that involved K–12 students in ecological monitoring projects.
Ho Yeong Yu, Seongjae Lee, Jae Geun Kim
wiley   +1 more source