Results 141 to 150 of about 92,604 (309)
Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis
, 2012 BackgroundOsteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of osteophytes.ObjectiveTo examine the hypothesis that inhibition of ...
Ruiz-Heiland, Gisela +29 more
core +1 more source
Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications
Barrier Immunity, EarlyView.A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu +9 more
wiley +1 more source
, 2022 SLIDE LABEL INFO: Hand 1: femur of hedgehog 374 USNM no. 172373 FROM INDEX CARD: Collection: USNM Spec #: 172373 Species: N/A Common Name: hedgehog Element: femur Side: N/A Notes: N/
Foote, James S., M.D.
core
Developmental Dynamics, EarlyView.Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu +4 more
wiley +1 more source
Identification of novel genes regulating the development of the palate
Developmental Dynamics, EarlyView.Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley +1 more source
Morphogenetic Signalling: Responses to Hedgehog
, 1995 Protein kinase A activity is required for signalling by the extracellular molecule Hedgehog in developing Drosophila imaginal discs, but does the kinase actually respond to the Hedgehog ...
Kalderon, Daniel
core +1 more source
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Functional Analysis of Hedgehog Signaling Pathways
, 2014 在無脊椎動物和脊椎動物的胚胎發育的過程中，Hedgehog 訊息傳導途徑控制了身體中軸前後方向的決定，並參與多種器官的形成[1-3]。近期以哺乳動物為材料的研究發現，Hedgehog 訊息傳導途徑在幹細胞更新、組織修復、及癌症的發生均扮演重要的角色[4-10]。目前利用遺傳學的方法，全世界果蠅的實驗室共同建立了Hedgehog 訊息傳導途徑的基本架構。簡略來說，細胞外的Hedgehog 蛋白質會與受體細胞膜上的受體蛋白質結合，並激活受體細胞內一系列的活化作用，最終傳導至轉錄因子cubitus ...
鄭旭辰
core
Developmental Dynamics, EarlyView.Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin +5 more
wiley +1 more source