Results 151 to 160 of about 92,604 (309)

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

open access: yesCNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi   +19 more
wiley   +1 more source

Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice

open access: yes, 2018
Meilin Liu, Xiaolong Chen, Henan Liu, Yu Di Department of Ophthalmology, Shengjing Affiliated Hospital, China Medical University, Shenyang, Liaoning, People’s Republic of China Aim: The aim of the study was to investigate the signal transduction ...
Liu HN, Liu ML, Chen XL, Di Y
core  

Fish-specific duplicated dmrt2b contributes to a divergent function through Hedgehog pathway and maintains left-right asymmetry establishment function.

open access: yes, 2009
Gene duplication is thought to provide raw material for functional divergence and innovation. Fish-specific dmrt2b has been identified as a duplicated gene of the dmrt2a/terra in fish genomes, but its function has remained unclear.
Liu Sha   +9 more
core   +1 more source

Genome-wide analysis of gene expression and alternative splicing in human medulloblastoma

open access: yes, 2010
Medulloblastoma is a malignant embryonal tumour of the cerebellum which most commonly affects children. A subset of tumours is thought to arise from cerebellar granule cell precursors (GCPs) that fail to undergo normal neuronal development, following ...
Menghi, F.
core  

Secretopathies emerge as a new class of neurocristopathies

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira   +3 more
wiley   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho   +6 more
wiley   +1 more source

Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors

open access: yes, 2015
Leslie A Fecher,1,3 William H Sharfman2 1Department of Internal Medicine and Dermatology, Indiana University Health Simon Cancer Center, Indianapolis, IN, USA; 2The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA ...
Sharfman WH, Fecher LA
core  

Species traits mediate the abundant‐center patterns in ground‐dwelling mammal and bird species in China

open access: yesEcography, EarlyView.
The abundance center hypothesis (ACH) posits that species abundance peaks at distribution centers; however, empirical support remains inconsistent. This study tested the generality of the ACH and investigated species traits as mediators of abundance–distance relationships.
Ludan Zhang   +7 more
wiley   +1 more source

Solar Fuels Via Methane Valorization: Thermochemical Pathways, Unified Metrics, and Techno‐Economic Perspectives

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A first‐of‐its‐kind review benchmarks three solar methane valorization pathways with unified performance metrics for clean fuel production. Meeting global climate targets and sustainable energy demands requires carbon‐neutral fuels and innovative conversion pathways.
Muhammad Abdulmoez   +3 more
wiley   +1 more source

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