Results 171 to 180 of about 162,439 (291)

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition

Drug Design, Development and Therapy
Juan Wang,1,* Hua Cheng,2,* Xinyue Zhao,1 Xiuwen Zhang,3 Xiaolei Ding,1 Taomin Huang3 1Department of Pharmacy, School of Medicine, Shanghai University, Shanghai, 200444, People’s Republic of China; 2Athinoula A.
Wang J, Cheng H, Zhao X, Zhang X, Ding X, Huang T   +5 more
doaj  

Activated Hedgehog signaling in keratocytes leads to stromal stiffness and impairs corneal regeneration. [PDF]

NPJ Regen Med
Yu Q, Li P, Du Z, Che M, Zhao H, Li B, Zhao P, Li J.   +7 more
europepmc   +1 more source

Uncovering the Genetic Landscape of Spinal Dysraphism: A Retrospective Analysis of 150 Fetal Cases

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Spinal dysraphism (SD) results from incomplete neural tube closure and encompasses a heterogeneous group of congenital anomalies with genetic and environmental etiologies. Although genetic contributions are recognized, causative variants remain insufficiently defined, and the clinical implications of extended genetic testing on ...
I. Bedei, A. Feresin, R. Zemet, D. Berner, D. Polidori, K. Fröbius, A. Skakkebæk, R. Axt‐Fliedner, M. Shoukier, C. Keil   +9 more
wiley   +1 more source

A transcriptomic resource for glial GABA-associated ASH neuronal aging and candidate pathways. [PDF]

Front Aging Neurosci
Al-Sheikh U, Cheng H, Bakrbaldawi AAA, He L, Chen D, Zhan R, Kang L, Zhang Y.   +7 more
europepmc   +1 more source

Exome Sequencing in Prenatally Diagnosed Isolated Neural Tube Defects: A Subtype‐Specific Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To explore potential genetic contributors across different subtypes of isolated neural tube defects (NTDs) ‐ acrania–exencephaly–anencephaly sequence (AEAS), spinal dysraphism, and encephalocele ‐ using exome sequencing (ES) in a prenatal cohort, with the goal of gaining insight into the molecular diversity underlying these distinct ...
Adi Botvinik, Vered Offen Glasner, Adi Reches, Hadas Miremberg, Karina Krajden Haratz, Tal brill, Liron Malki, Michal Rozenzwaig, Yuval Yaron, Michal Levy   +9 more
wiley   +1 more source

Liver-derived Indian hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis. [PDF]

Mol Metab
Teperino R, Adamová M, Aljabali SM, Pai S, Gerlini R, Paez-Perez I, Matz-Soja M, Heyne S, Lempradl A, Basilicata MF, Hrabě de Angelis M, Gebhardt R, Schleicher E, Häring HU, Pospisilik JA.   +14 more
europepmc   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

[Corrigendum] Astragaloside IV promotes the proliferation and migration of osteoblast‑like cells through the hedgehog signaling pathway. [PDF]

Int J Mol Med
Guo LH, Cao Y, Zhuang RT, Han Y, Li J.
europepmc   +1 more source

Sampling, Mobility, and Anchoring in Small‐Body Sampling Robots: A Comprehensive Review

SmartBot, EarlyView.
Small‐body sampling robots are exploration systems that perform contact, sampling, and stable operations on microgravity bodies such as asteroids and comets. The authors review representative robot architectures and key technologies, focusing on the mechanisms, evolution, and coupling of sampling, mobility, and anchoring.
Yurui Shen, Yixin Zhu, Mingxia Bao, Ting Zhang, Jun Wu, Jingbin Hao, Dezheng Hua, Xinhua Liu   +7 more
wiley   +1 more source