Results 191 to 200 of about 101,813 (256)

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Wuguchong Bioactive Peptides Promote Wound Healing via Hedgehog Pathway‑Mediated Fibroblast Modulation. [PDF]

Chem Biodivers
Li K, Sun Y, Pang L, Gao T, Diao Y, Fan S.   +5 more
europepmc   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Hedgehog signaling enhances the Schwann-like and nerve repair-supportive properties of ectomesenchymal stem cells. [PDF]

Front Neurosci
Zhang D, Bian R, Ma Y, Yuan H, Wu X, Tang H, Zhao F.   +6 more
europepmc   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Tendon stem/progenitor cells in heterotopic ossification: functional regulation, molecular mechanisms and targeted therapeutic strategies. [PDF]

J Orthop Translat
Zhu X, Gao Y, Cai M, Jiang H, Gao R, Tang H, Liu T, Zhou X, Lai B.   +8 more
europepmc   +1 more source

A systematic review and meta‐analysis of variation in nest predation of ground‐nesting birds

Ibis, EarlyView.
Predation and communities of predators of ground‐nesting bird nests and fledglings have been studied across multiple groups of ground‐nesting birds, such as waders, waterbirds, gamebirds and passerines, and habitats, but differences and similarities between groups are less studied.
Mari D. Klaussen, Kevin A. Wood, Alex Nicol‐Harper, Anita Diaz Isla, Emilie A. Hardouin, Richard A. Stillman   +5 more
wiley   +1 more source

Itraconazole in Low-Risk Basal Cell Carcinoma: Stabilisation Before Downstaging. [PDF]

Exp Dermatol
Wan H, Quan G.
europepmc   +1 more source