Results 81 to 90 of about 74,143 (263)
Frontiers in Cell and Developmental BiologyMitotic spindle orientation is crucial for cell fate determination and tissue organization. Although the intracellular machinery governing spindle orientation is well characterized, whether and how secreted factors, such as morphogens, regulate this ...
Fengming Liu +8 more
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Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity
Molecules, 2016 The major obstacle limiting the efficacy of current Smoothened (Smo) inhibitors is the primary and acquired resistance mainly caused by Smo mutations and Gli amplification.
Jun Yang, Wenjing Huang, Wenfu Tan
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Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
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Loss, persistence and reversal of phenotypic traits
Biological Reviews, EarlyView.ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni +4 more
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Humans are not unique: difficult birth is common in placental mammals
Biological Reviews, EarlyView.ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
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Blisko ziemi. Kilka lekcji jeża
Zoophilologica, 2015 Reading Jacques Derrida’s essay Che cos’è la poesia? as well as poems by Rainer Maria Rilke, Thomas Hardy, and Tadeusz Kijonka, we want to argue that the animal helps us to redefine the human subject.
Tadeusz Sławek
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Chemistry – A European Journal, EarlyView.The polyoxo‐20‐molybdate(VI) wheel [MoVI20O60{AsO2(CH3)2}12]12− (Mo20) can be prepared with or without a central guest in a controlled, cation‐directed fashion. When Mo20 is dissolved in water, it exhibits an immediate, quantitative, and fully reversible solution transformation to a tetranuclear Mo4 cluster, which transforms in the solid state again to
Arun Pal +12 more
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Clinical Pharmacology &Therapeutics, EarlyView.Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović +11 more
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BiomedicinesNon-melanoma skin cancers (NMSC) form the majority of skin cancers, with basal cell carcinoma (BCC) being the most common and cutaneous squamous cell carcinoma (cSCC) being second.
Zoe Gabrielle Attal +8 more
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Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
Cells, 2019 Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine drug resistance and provide
Natalia A. Riobo-Del Galdo +2 more
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