Results 61 to 70 of about 162,439 (291)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Cleavage activates Dispatched for Sonic Hedgehog ligand release

eLife, 2018
Hedgehog ligands activate an evolutionarily conserved signaling pathway that provides instructional cues during tissue morphogenesis, and when corrupted, contributes to developmental disorders and cancer.
Daniel P Stewart, Suresh Marada, William J Bodeen, Ashley Truong, Sadie Miki Sakurada, Tanushree Pandit, Shondra M Pruett-Miller, Stacey K Ogden   +7 more
doaj   +1 more source

The Hedgehog Pathway as a Therapeutic Target in Chronic Myeloid Leukemia

Pharmaceutics, 2023
Despite the development of therapeutic agents that selectively target cancer cells, relapse driven by acquired drug resistance and resulting treatment failure remains a significant issue.
Andrew Wu, Kelly A. Turner, Adrian Woolfson, Xiaoyan Jiang   +3 more
doaj   +1 more source

Approximate solutions for the skyrmion [PDF]

, 2001
We reconsider the Euler-Lagrange equation for the Skyrme model in the hedgehog ansatz and study the analytical properties of the solitonic solution. In view of the lack of a closed form solution to the problem, we work on approximate analytical solutions.
Canal, C. A. Garcia, Epele, L. N., Fanchiotti, H., Ponciano, J. A.   +3 more
core   +2 more sources

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Do Urban Hedgehogs (Erinaceus europaeus) Represent a Relevant Source of Zoonotic Diseases?

Pathogens, 2023
Urban fauna is defined as animal species that can live in urban environments. Several species, including the western-European hedgehog (Erinaceus europaeus), have now been identified as part of this urban fauna, becoming permanent residents of parks and ...
Catarina Jota Baptista, Paula A. Oliveira, José M. Gonzalo-Orden, Fernanda Seixas   +3 more
doaj   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Salmonellosis in Hedgehogs

Veterinary Clinics of North America: Exotic Animal Practice, 2020
African pygmy hedgehogs are popular pets worldwide. The knowledge and understanding of pet hedgehog common veterinary conditions are increasing as new information and research are published; however, there is still much to learn about this fascinating animal.
Keeble, Emma, Koterwas, Bronwyn
openaire   +4 more sources

Response of nucleons to external probes in hedgehog models: II. General formalism

, 1992
Linear response theory for SU(2) hedgehog soliton models is developed.Comment: 25 pages, DOE/ER/40322-163, U.
A. Kerman, B. Golli, B. Schwesinger, C.-Y. Ren, D. I. Dyakonov, D. I. Dyakonov, D. I. Dyakonov, D. J. Rowe, E. Witten, E. Witten, G. 't Hooft, G. Kalberman, G. R. S. Kahana, G. S. Adkins, G. S. Adkins, H. Reinhardt, I. Duck, I. J. R. Aitchison, I. J. R. Aitchison, I. J. R. Aitchison, I. Zahed, J. A. Zuk, J. Goldstone, L. Vepstas, M. C. Birse, M. C. Birse, M. C. Birse, M. C. Birse, M. Fiolhais, M. Gell-Mann, M. K. Banerjee, M. K. Banerjee, P. Ring, R. Alkofer, R. Friedberg, R. I. Nepomechi, R. Jackiw, R. Jackiw, S. A. Chin, S. Kahana, T. D. Cohen, T. D. Cohen, T. Eguchi, T. H. R. Skyrme, T. H. R. Skyrme, Th. Meissner, Th. Meissner, Thomas D. Cohen, V. I. Arnold, W. Broniowski, W. Broniowski, W. Broniowski, W. Broniowski, W. Broniowski, W. Broniowski, W. Broniowski, Wojciech Broniowski, Y. Nambu   +57 more
core   +1 more source

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation [PDF]

, 2019
The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA‑approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown limited
Agostinelli, Enzo, Antonucci, Laura, Bordone, Rosa, Caimano, Miriam, Canettieri, Gianluca, Capalbo, Carlo, Checquolo, Saula, Coni, Sonia, D'Amico, Davide, De Smaele, Enrico, Di Magno, Laura, Di Marcotullio, Lucia, Di Pastena, Fiorella, Giorgi, Alessandra, Manni, Simona, Maroder, Marella, Petroni, Marialaura, Schininà, Maria Eugenia, Serrao, Silvia Maria, Yates Iii, John R, Yurtsever, Zuleyha Nihan   +20 more
core   +1 more source