Results 51 to 60 of about 101,813 (256)
Lipid metabolism fattens up hedgehog signaling [PDF]
, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Robert Blassberg (9078959) +3 more
core +1 more source
Multimodal Human–Robot Interaction Using Human Pose Estimation and Local Large Language Models
Advanced Robotics Research, EarlyView.A multimodal human–robot interaction framework integrates human pose estimation (HPE) and a large language model (LLM) for gesture‐ and voice‐based robot control. Speech‐to‐text (STT) enables voice command interpretation, while a safety‐aware arbitration mechanism prioritizes gesture input for rapid intervention.
Nasiru Aboki +2 more
wiley +1 more source
Cleavage activates Dispatched for Sonic Hedgehog ligand release
eLife, 2018 Hedgehog ligands activate an evolutionarily conserved signaling pathway that provides instructional cues during tissue morphogenesis, and when corrupted, contributes to developmental disorders and cancer.
Daniel P Stewart +7 more
doaj +1 more source
Do Urban Hedgehogs (Erinaceus europaeus) Represent a Relevant Source of Zoonotic Diseases?
Pathogens, 2023 Urban fauna is defined as animal species that can live in urban environments. Several species, including the western-European hedgehog (Erinaceus europaeus), have now been identified as part of this urban fauna, becoming permanent residents of parks and ...
Catarina Jota Baptista +3 more
doaj +1 more source
The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers [PDF]
, 2010 Background: The hedgehog signaling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are being developed for potential use in cancer. Objectives/Methods: The objective of this evaluation
Doggrell, Sheila Anne, Sheila A Doggrell
core +1 more source
Distributed Micropneumatic Sensors for Soft Robots to Detect Touch and Pose
Advanced Robotics Research, EarlyView.Soft robots need integrated touch and pose sensing for safe and reliable operation. This work presents a three‐fingered soft gripper with 18 micropneumatic sensors made from the same materials as its pneumatic actuators. By measuring airflow resistance changes in deforming microchannels of the sensors, finger pose and contact are detected, enabling ...
Vilma Lampinen +3 more
wiley +1 more source
The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts [PDF]
, 2009 The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer.
Aubie Shaw, Jerry Gipp, Wade Bushman
core
Advanced Science, EarlyView.Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong +20 more
wiley +1 more source
Quantitative Immunoblotting of Endogenous Hedgehog Pathway Components
, 2015 Quantitative analysis and modeling of signaling pathway components can reveal important information about the dynamics of that system, including the relative stoichiometries and affinities between the individual signaling components, as well as rate ...
Robbins, David J +3 more
core +1 more source
Time-resolved proteomics profiling of the ciliary Hedgehog response [PDF]
, 2021 The primary cilium is a signaling compartment that interprets Hedgehog signals through changes of its protein, lipid, and second messenger compositions.
Nachury, Maxence V +13 more
core +1 more source