Results 31 to 40 of about 92,604 (309)

Hedgehogs and Hedgehog-Head Boats in Ancient Egyptian Religion in the Late 3rd Millennium BCE

Arts, 2022
Hedgehogs held a special place in ancient Egyptian life like many other desert- and marsh-dwelling animals. Their natural defensive qualities were admired by ancient Egyptians and their bodily parts, notably their hardened spines, were used as ...
Julia Clare Francis Hamilton
doaj   +1 more source

Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. [PDF]

, 2013
Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (Gli1 ...
Hennen, Elisabeth, Olga Bermudez, Oliver Eickelberg, Olga Bermudez (410727), Ina Koch (7903), Oliver Eickelberg (153848), Eickelberg, O., Bermudez, O., Koch, I., Lindner, Michael, Elisabeth Hennen, Hennen, E., Koch, Ina, Elisabeth Hennen (410728), Bermudez, Olga, Michael Lindner, Ina Koch, Michael Lindner (383308), Lindner, M., Eickelberg, Oliver   +19 more
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T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

eLife, 2016
Crucial roles for T-box3 in development are evident by severe limb malformations and other birth defects caused by T-box3 mutations in humans. Mechanisms whereby T-box3 regulates limb development are poorly understood.
Uchenna Emechebe, Pavan Kumar P, Julian M Rozenberg, Bryn Moore, Ashley Firment, Tooraj Mirshahi, Anne M Moon   +6 more
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Crenosoma striatum in lungs of European hedgehogs (Erinaceus europeus) from Portugal

Helminthologia, 2020
Crenosoma striatum is a host-specifi c metastrongiloid nematode causing respiratory tract disease in hedgehogs (Erinaceus europaeus). Since few studies have reported C.
Barradas P. F., Flores A. R., Mateus T. L., Carvalho F., Gärtner F., Amorim I., Mesquita J. R.   +6 more
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Wild Hedgehogs and Their Parasitic Ticks Coinfected with Multiple Tick-Borne Pathogens in Jiangsu Province, Eastern China

Microbiology Spectrum, 2022
The increasing awareness of emerging tickborne pathogens (TBPs) has inspired much research. In the present study, the coinfections of TBPs both in ticks and their wild hedgehog hosts in Jiangsu province, Eastern China were determined by metagenome next ...
Yong Qi, Lele Ai, Changqiang Zhu, Fuqiang Ye, Ruichen Lv, Junhu Wang, Yingqing Mao, Nianhong Lu, Weilong Tan   +8 more
doaj   +1 more source

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]

Nature Chemical Biology, 2013
Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta, Rios-Esteves, Jessica, Ouerfelli, Ouathek, Glickman, J. Fraser, Resh, Marilyn D.   +4 more
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HEDGEHOGS IN LEHMER’S PROBLEM [PDF]

Bulletin of the Australian Mathematical Society, 2021
AbstractMotivated by a famous question of Lehmer about the Mahler measure, we study and solve its analytic analogue.
JAN-WILLEM M. VAN ITTERSUM, BEREND RINGELING, WADIM ZUDILIN   +2 more
openaire   +5 more sources

CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells

Frontiers in Cell and Developmental Biology, 2020
Primary cilia are hair-like projections that protrude from most mammalian cells and mediate various extracellular signaling pathways. Pancreatic ductal adenocarcinoma (PDAC) cells are known to lose their primary cilia, but the relevance of this ...
Tetsuo Kobayashi, Kosuke Tanaka, Yu Mashima, Ayano Shoda, Mio Tokuda, Hiroshi Itoh   +5 more
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Endoparasite Infections of the European Hedgehog (Erinaceus europaeus) in Central Italy

Animals, 2021
The European hedgehog is a synanthropic mammal, widely distributed in Europe. This species usually inhabits the edges of deciduous or mixed woods, but it is also very common in private gardens and public parks.
Alessia Mariacher, Andrea Santini, Irene Del Lesto, Sara Tonon, Elena Cardini, Antonino Barone, Claudia Eleni, Gianluca Fichi, Stefania Perrucci   +8 more
doaj   +1 more source

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

, 2009
We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V, Ross, Susan E, Rowbotham, Nicola J, Crompton, T, Hager-Theodorides, Ariadne L, Shah, DK, Shah, Divya K, Drakopoulou, Ekati, Lanske, Beate, Crompton, Tessa, Dessens, Johannes T, Drakopoulou, E, Rowbotham, NJ, Dessens, JT, Ross, SE, Lanske, B, Outram, SV, Hager-Theodorides, AL   +17 more
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