Results 11 to 20 of about 92,604 (309)

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan

Cell Reports, 2020
Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis, Juan A. Navarro, Mathias Rass, Amélie Hu, Serge Birman, Stephan Schneuwly, Pascal P. Thérond   +6 more
doaj   +2 more sources

Genetic basis for skeletal new bone formation [PDF]

Exploration of Musculoskeletal Diseases, 2023
Bone formation is a complex process that occurs throughout life, and is normally limited to the skeletal system. In bone formation, osteoprogenitor cells follow several developmental stages, including differentiation in osteoblasts, proliferation, matrix
Bruna Parreira, Ana Rita Couto, Luís Pinheiro, Jácome Bruges-Armas   +3 more
doaj   +1 more source

Hedgehog Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Hedgehog (Hh) proteins constitute one family of a small number of secreted signaling proteins that together regulate multiple aspects of animal development, tissue homeostasis and regeneration. Originally uncovered through genetic analyses in Drosophila, their subsequent discovery in vertebrates has provided a paradigm for the role of morphogens in ...
Siu Wah, Choy, Shuk Han, Cheng
openaire   +5 more sources

Morphological description and histological structure of the Hedgehog Kidney (Hemiechinus auritus)

Tikrit Journal of Pure Science, 2023
This study was aimed to recognize the morphological description and histological structure of the kidney in hedgehog (Hemiechinus auritus). The morphological results showed that the kidney has a small bean shape and reddish brown color.
Thekra Atta, Mohammed Nsaif Abbas, Luay Qasim, Ashwaq Talib, Mohammed Ali   +4 more
doaj   +1 more source

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

eLife, 2022
The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.
Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam   +5 more
doaj   +1 more source

Hibernation Patterns of the European Hedgehog, Erinaceus europaeus, at a Cornish Rescue Centre

Animals, 2020
The European hedgehog, Erinaceus europaeus, is frequently admitted to rescue centres in the UK. With many overwintering in captivity, there is cause to investigate hibernation patterns in order to inform and improve husbandry and monitoring protocols ...
Kathryn E. South, Kelly Haynes, Angus C. Jackson   +2 more
doaj   +1 more source

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

Cells, 2023
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling.
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian   +8 more
doaj   +1 more source

gatoravi/hedgehog-variability:

, 2022
v1.0.0 of the notebooks used in the hedgehog variability ...
Avinash R
core   +2 more sources

Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions

Frontiers in Molecular Biosciences, 2023
Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth and
Dominique Manikowski, Georg Steffes, Jurij Froese, Sebastian Exner, Kristina Ehring, Fabian Gude, Daniele Di Iorio, Seraphine V. Wegner, Kay Grobe   +8 more
doaj   +1 more source

Hedgehogs as Amplifying Hosts of Severe Fever with Thrombocytopenia Syndrome Virus, China

Emerging Infectious Diseases, 2022
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tickborne bandavirus mainly transmitted by Haemaphysalis longicornis ticks in East Asia, mostly in rural areas.
Chaoyue Zhao, Xing Zhang, Xiaoxi Si, Ling Ye, Kevin Lawrence, Yajun Lu, Chunhong Du, Haidong Xu, Qian Yang, Qianfeng Xia, Guoxiang Yu, Wei Xu, Fei Yuan, Junfeng Hao, Jia-Fu Jiang, Aihua Zheng   +15 more
doaj   +1 more source