Results 11 to 20 of about 162,439 (291)

Genetic basis for skeletal new bone formation [PDF]

open access: yesExploration of Musculoskeletal Diseases, 2023
Bone formation is a complex process that occurs throughout life, and is normally limited to the skeletal system. In bone formation, osteoprogenitor cells follow several developmental stages, including differentiation in osteoblasts, proliferation, matrix
Bruna Parreira   +3 more
doaj   +1 more source

Hedgehog Signaling [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2012
Hedgehog (Hh) proteins constitute one family of a small number of secreted signaling proteins that together regulate multiple aspects of animal development, tissue homeostasis and regeneration. Originally uncovered through genetic analyses in Drosophila, their subsequent discovery in vertebrates has provided a paradigm for the role of morphogens in ...
Siu Wah, Choy, Shuk Han, Cheng
openaire   +5 more sources

Morphological description and histological structure of the Hedgehog Kidney (Hemiechinus auritus)

open access: yesTikrit Journal of Pure Science, 2023
This study was aimed to recognize the morphological description and histological structure of the kidney in hedgehog (Hemiechinus auritus). The morphological results showed that the kidney has a small bean shape and reddish brown color.
Thekra Atta   +4 more
doaj   +1 more source

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

open access: yeseLife, 2022
The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.
Marina Gonçalves Antunes   +5 more
doaj   +1 more source

Hibernation Patterns of the European Hedgehog, Erinaceus europaeus, at a Cornish Rescue Centre

open access: yesAnimals, 2020
The European hedgehog, Erinaceus europaeus, is frequently admitted to rescue centres in the UK. With many overwintering in captivity, there is cause to investigate hibernation patterns in order to inform and improve husbandry and monitoring protocols ...
Kathryn E. South   +2 more
doaj   +1 more source

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

open access: yesCells, 2023
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling.
Ping Shi   +8 more
doaj   +1 more source

Hedgehog Hives [PDF]

open access: yesArchives of Dermatology, 1999
Hedgehogs are increasingly popular pets in the United States and Europe. A number of infections may be acquired from these animals, and hedgehogs are possible hosts of parasites. However, to our knowledge there arc no previous reports of urticarial reactions to hedgehogs.We describe 3 patients who developed an acute, transient, urticarial reaction ...
J A, Fairley, J, Suchniak, A S, Paller
openaire   +2 more sources

Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions

open access: yesFrontiers in Molecular Biosciences, 2023
Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth and
Dominique Manikowski   +8 more
doaj   +1 more source

Hedgehogs as Amplifying Hosts of Severe Fever with Thrombocytopenia Syndrome Virus, China

open access: yesEmerging Infectious Diseases, 2022
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tickborne bandavirus mainly transmitted by Haemaphysalis longicornis ticks in East Asia, mostly in rural areas.
Chaoyue Zhao   +15 more
doaj   +1 more source

Hedgehog signalling [PDF]

open access: yesDevelopment, 2016
The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic ...
Lee, Raymond Teck Ho   +2 more
openaire   +3 more sources

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