Results 21 to 30 of about 74,143 (263)
Microbiology Spectrum, 2022 The increasing awareness of emerging tickborne pathogens (TBPs) has inspired much research. In the present study, the coinfections of TBPs both in ticks and their wild hedgehog hosts in Jiangsu province, Eastern China were determined by metagenome next ...
Yong Qi +8 more
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Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]
Nature Chemical Biology, 2013 Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta +4 more
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Hedgehog Signaling Modulates Glial Proteostasis and Lifespan
Cell Reports, 2020 Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis +6 more
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CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells
Frontiers in Cell and Developmental Biology, 2020 Primary cilia are hair-like projections that protrude from most mammalian cells and mediate various extracellular signaling pathways. Pancreatic ductal adenocarcinoma (PDAC) cells are known to lose their primary cilia, but the relevance of this ...
Tetsuo Kobayashi +5 more
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Frontiers in SustainabilityAirports, the essential hubs of global travel, have to cater for the increasing demands for air travel, with growing passenger numbers and the associated growth in resource consumption.
Anne van der Tuin-Rademaker +5 more
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Endoparasite Infections of the European Hedgehog (Erinaceus europaeus) in Central Italy
Animals, 2021 The European hedgehog is a synanthropic mammal, widely distributed in Europe. This species usually inhabits the edges of deciduous or mixed woods, but it is also very common in private gardens and public parks.
Alessia Mariacher +8 more
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Study of Zoonotic Enteric Pathogens of Atelerix algirus in Tenerife, Canary Islands, Spain
Frontiers in Veterinary Science, 2020 Atelerix algirus is an invasive species in the Canary Islands (Spain). There are few studies about the zoonotic pathogens this species could be hosting; therefore, this study was focused on analyzing causative agents of diarrhea in humans in feces from ...
Elena Izquierdo-Rodriguez +5 more
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European Journal of BiologyObjective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
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Frontiers in Cell and Developmental Biology, 2023 Objective: The nucleus pulposus (NP) comprises notochordal NP cells (NCs) and chondrocyte-like NP cells (CLCs). Although morphological similarities between CLCs and chondrocytes have been reported, interactions between CLCs and NCs remain unclear.
Hiroki Hagizawa +7 more
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Reasons for admission and rehabilitation rates of various wildlife species in Finland
Frontiers in Veterinary ScienceWildlife rehabilitation is a common part of animal-protection work. In Finland wildlife care is usually based on volunteer work and no licensing or training is required.
Kati White +4 more
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