Results 41 to 50 of about 162,439 (291)

Critical Phenomena Inside Global Monopoles [PDF]

open access: yes, 1999
The gravitational collapse of a triplet scalar field is examined assuming a hedgehog ansatz for the scalar field. Whereas the seminal work by Choptuik with a single, strictly spherically symmetric scalar field found a discretely self-similar (DSS ...
C. Gundlach   +6 more
core   +2 more sources

Notch and Hedgehog Signalling Axis Drive Senescence in HER2-Positive Breast Cancer Resistant to Trastuzumab

open access: yesEuropean Journal of Biology
Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
doaj   +1 more source

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]

open access: yesNature Chemical Biology, 2013
Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta   +4 more
openaire   +2 more sources

Reasons for admission and rehabilitation rates of various wildlife species in Finland

open access: yesFrontiers in Veterinary Science
Wildlife rehabilitation is a common part of animal-protection work. In Finland wildlife care is usually based on volunteer work and no licensing or training is required.
Kati White   +4 more
doaj   +1 more source

Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding

open access: yesMolecules, 2019
Sonic hedgehog (Shh) signaling plays a tumor-promoting role in many epithelial cancers. Cancer cells produce soluble a Shh that signals to distant stromal cells that express the receptor Patched (Ptc).
Dominique Manikowski   +3 more
doaj   +1 more source

Craniofacial Osteosarcoma—Pilot Study on the Expression of Osteobiologic Characteristics and Hypothesis on Metastasis

open access: yesFrontiers in Oncology, 2020
Background: Craniofacial osteosarcomas (COS) and extracranial osteosarcomas (EOS) show distinct clinical differences. COS show a remarkably lower incidence of metastases and a better survival.
Manuel Weber   +6 more
doaj   +1 more source

COVID‐19 lockdown measures impacted citizen science hedgehog observation numbers in Bavaria, Germany

open access: yesEcology and Evolution, 2022
The COVID‐19 pandemic has led to temporary changes in human–animal interactions due to changes in human activities. Here, we report on a surge in hedgehog observations during the first COVID‐19 lockdown in Germany in 2020, on the citizen science Web ...
Fabio S. T. Sweet   +2 more
doaj   +1 more source

Detection and Control of Dermatophytosis in Wild European Hedgehogs (Erinaceus europaeus) Admitted to a French Wildlife Rehabilitation Centre

open access: yesJournal of Fungi, 2021
The rising number of European hedgehogs (Erinaceus europaeus) admitted every year to wildlife rehabilitation centres might be a source of concern to animal and public health since transmissible diseases, such as dermatophytosis, can be easily ...
Cécile Le Barzic   +6 more
doaj   +1 more source

Case Report: Metastatic renal giant-cell sarcoma in an African pygmy hedgehog (Atelerix albiventris)

open access: yesFrontiers in Veterinary Science
The scientific literature referring to tumors in African pygmy hedgehog (Atelerix albiventris) is expanding, enhanced by an increased lifespan under human care.
Pablo Díaz-Santana   +3 more
doaj   +1 more source

Invasive Urban Mammalian Predators: Distribution and Multi-Scale Habitat Selection

open access: yesBiology, 2022
A barrier to successful ecological restoration of urban green spaces in many cities is invasive mammalian predators. We determined the fine- and landscape-scale habitat characteristics associated with the presence of five urban predators (black and brown
Kim F. Miller   +6 more
doaj   +1 more source

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