Results 91 to 100 of about 92,604 (309)

Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish

BMC Biology, 2012
Background How and why animals lose eyesight during adaptation to the dark and food-limited cave environment has puzzled biologists since the time of Darwin.
Yoshizawa Masato, Yamamoto Yoshiyuki, O'Quin Kelly E, Jeffery William R   +3 more
doaj   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Environmental and Habitat Preferences of the Algerian Hedgehog Atelerix Algirus(Lereboullet, 1842) in El Kala National Park (NorthEast Algeria)

Journal of Bioresource Management, 2022
We conducted this study to identify the preferred habitat of Atelerix algirus in the National Park of El Kala (PNEK), through the analysis of the catches rates of the species combined to an ethno zoological survey carried out among the residents.
Sakraoui Rym, Boukheroufa Mehdi , Dadci Walid , Abdallah Khadidjawissal , Senaoui Charafeddine   +4 more
doaj  

Studio dei meccanismi autocrini e paracrini di attivazione di Hedgehog in modelli tumorali umani.

, 2011
La trasduzione del segnale sotto il controllo di Hedgehog (HH) è coinvolta nella patogenesi e nella progressione di diverse neoplasie umane, ma i meccanismi molecolari di attivazione sono noti solo in parte.
BIANCO, ROBERTO
core  

The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers

, 2010
Background: The hedgehog signaling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are being developed for potential use in cancer. Objectives/Methods: The objective of this evaluation
Doggrell, Sheila Anne
core   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Does urbanisation have an impact on the trophic ecology of the Algerian hedgehog Atelerix algirus in northern Algeria? [PDF]

Biodiversity Data Journal
The Algerian hedgehog, which is an endemic Mediterranean species, is a nocturnal and terrestrial insectivorous mammal. Atelerix algirus’ populations are widespread in various habitats comprising human agglomeration, such as rural, suburban or natural ...
Amina Zidane, Ilham Sahki-Benabbas, Mohamed Ayoub Rahal, Riadh Moulaî   +3 more
doaj   +3 more sources

Partial hearing recovery after cochlear nerve surface transplantation of hair follicle‐derived neural crest stem cells in neural hearing loss rat

Animal Models and Experimental Medicine, EarlyView.
This study comprises three experimental parts. Part 1. Time‐course of ouabain‐induced hearing loss. Rats received ouabain (10 mM) via round window application. ABR/DPOAE tests and histological analyses were performed at 2, 7, and 30 days post‐treatment to characterize SGN and glial cell degeneration. Part 2.
Huidong Chen, Yunlong Zhang, Huanzhi Wan, Bingqian Yang, Tianyi Liu, Jie Wang, Hua Liao, Yuanyuan Zhang, Zhijian Zhang, Qingquan Hua   +9 more
wiley   +1 more source

Genome-wide identification of Hand2 target regions in mouse embryos using dRMCE, a new genetic tool [PDF]

, 2012
Limb bud development is a paradigmatic model to study the molecular signals that orchestrate cell growth and behaviour. Anterior-posterior patterning of the limb bud mesenchyme is dependent on the secreted ligand Sonic hedgehog (Shh).
Osterwalder, Marco
core   +1 more source

Evaluation of IHH, PTCH1, and SMO protein immunohistochemistry in the human mandibular condyle at fetal stages from 30 to 80 mm greatest length

The Anatomical Record, EarlyView.
Abstract This study evaluated the morphogenesis of the temporomandibular joint (TMJ) in human fetuses during the third month of gestation through the analysis of immunohistochemistry for the proteins Indian Hedgehog (IHH), Patched‐1 (PTCH1), and Smoothened (SMO).
Filipe Santos da Silva, Carolina de Oliveira Gigek, Andreia Fabiana Do Vale Franco, Amanda Alves Ribeiro Massoni, José Ramon Mérida‐Velasco, Luís Otávio Carvalho de Moraes   +5 more
wiley   +1 more source