Results 91 to 100 of about 101,813 (256)

Hedgehog, left femur of Erinaceus

, 2022
SLIDE LABEL INFO: Hand 1: Left femur of Hedgehog-Erinaceus 233. AMNH FROM INDEX CARD: Collection: AMNH Spec #: N/A Species: Erinaceus Common Name: hedgehog Element: femur Side: L Notes: N/
Foote, James S., M.D.
core  

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Hedgehog signaling controls astral microtubules and mitotic spindle orientation in neural progenitors and iPSCs

Frontiers in Cell and Developmental Biology
Mitotic spindle orientation is crucial for cell fate determination and tissue organization. Although the intracellular machinery governing spindle orientation is well characterized, whether and how secreted factors, such as morphogens, regulate this ...
Fengming Liu, Anna Medyukhina, Kris M. Olesen, Abbas Shirinifard, Hongjian Jin, Lei Li, Marina Mapelli, Khaled Khairy, Young-Goo Han   +8 more
doaj   +1 more source

SHH (Sonic hedgehog) [PDF]

, 2002
Review on SHH (Sonic hedgehog), with data on DNA, on the protein encoded, and where the gene is ...
Magnaldo, T
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP [PDF]

, 2009
Hedgehog (Hh) morphogens have fundamental roles in development, whereas dysregulation of Hh signaling leads to disease. Multiple cell-surface receptors are responsible for transducing and/or regulating Hh signals.
A Radu Aricescu, O'Callaghan, Chris A, Aricescu, Alexandru, Bishop, B, Siebold, Christian, Harlos, Karl, E Yvonne Jones, O'Callaghan, Christopher, Christian Siebold, Bishop, Benjamin, Jones, Edith, Harlos, K, Jones, E Yvonne, Chris A O'Callaghan, Karl Harlos, Benjamin Bishop, Aricescu, Alexandru R   +16 more
core   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Numb is a suppressor of Hedgehog signaling and targets Gli1 for Itch-dependent ubiquitination.

, 2006
The developmental protein Numb is a major determinant of binary cell fates(1-3). It is also required for the differentiation of cerebellar granule cell progenitors (GCPs)(4) at a stage of development responsive to the morphogenic glycoprotein Hedehog(5,6)
FERRETTI, ELISABETTA, MARODER M, SCREPANTI I, GRECO A, AND GULINO A., PO, AGNESE, DI MARCOTULLIO L, GIANNINI G, DE SMAELE, Enrico, ALIMANDI, MAURIZIO   +9 more
core  

Regulation of netrin-1a expression by hedgehog proteins

, 1998
Netrins, a family of growth cone guidance molecules, are expressed both in the ventral neural tube and in subsets of mesodermal cells. In an effort to better understand the regulation of netrins, we examined the expression of netrin-1a in mutant cyclops,
Schauerte, H., Haffter, P., Fazel, R., Lauderdale, J., van Eeden, F. ; https://orcid.org/, Kuwada, J., Pasquali, S.   +6 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source