Results 51 to 60 of about 49,844 (160)
Activation of hedgehog signaling is not a frequent event in ovarian cancers
Molecular Cancer, 2009 The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer.
Zhang Xiaoli +7 more
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The Role of GLI-1 in Endocrine Resistant Breast Cancer [PDF]
, 2014 Estrogen receptor positive (ER+) and estrogen receptor negative (ER-) are two major types of breast cancer. For women with ER+ positive breast cancer, patients are treated with the antiestrogenic compounds, tamoxifen or faslodex for five years ...
Rudolph, Mark
core
Hedgehog Signaling Pathway and Lung Cancer [PDF]
Journal of Thoracic Oncology, 2007 Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events resulting in the development of neoplasia. We review the biology of the hedgehog signaling pathway and
Velcheti, Vamsidhar, Govindan, Ramaswamy
openaire +2 more sources
Cell Death and Disease, 2017 mTORC2 is aberrantly activated in cancer and therefore is considered to be an important therapeutic target. The hedgehog pathway, which is also often hyperactivated, regulates transcription of several genes associated with angiogenesis, metastasis ...
Samarpan Maiti +3 more
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Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [PDF]
, 2007 Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network.
Davidson, Eric H. +9 more
core +2 more sources
A highlight on Sonic hedgehog pathway
Cell Communication and Signaling, 2018 Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of tumors. Most of the brain tumors are resistant to chemotherapeutic drugs, consequently, they have a poor
Gabriela Basile Carballo +3 more
openaire +3 more sources
Patched receptors sense, interpret and establish an epidermal Hedgehog signalling gradient [PDF]
, 2016 By using the sensitivity of single-molecule fluorescent in situ hybridization, we have precisely quantified the levels and defined the temporal and spatial distribution of Hedgehog signaling activity during embryonic skin development and discovered that ...
Adolphe, Christelle +4 more
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Prostate cancer and Hedgehog signalling pathway [PDF]
Clinical and Translational Oncology, 2007 The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates.
Antón-Aparicio, Luis M. +6 more
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Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
Acta Neuropathologica Communications, 2020 Meningiomas are the most common primary intracranial tumors, but treatment options for meningioma patients are limited due to incomplete understanding of tumor biology.
Sarah Findakly +5 more
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In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter. [PDF]
PLoS ONE, 2014 The Hedgehog (Hh) pathway is essential for embryonic development and tissue regeneration, and its dysregulation can lead to birth defects and tumorigenesis.
John K Mich +3 more
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