Results 51 to 60 of about 2,340,031 (328)
The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
Dose-Response, 2019 Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and ...
Chang Liu, Rensheng Wang
doaj +1 more source
Smoothened as a new therapeutic target for human osteosarcoma
Molecular Cancer, 2010 Background The Hedgehog signaling pathway functions as an organizer in embryonic development. Recent studies have demonstrated constitutive activation of Hedgehog pathway in various types of malignancies.
Nagao Hiroko +7 more
doaj +1 more source
Targeting the Hedgehog Pathway in Cancer: Current Evidence and Future Perspectives
Cells, 2019 The Hedgehog pathway (HhP) plays an important role in normal embryonic development and its abnormal function has been linked to a variety of neoplasms.
D. Girardi +3 more
semanticscholar +1 more source
Hedgehog Signaling Modulates Glial Proteostasis and Lifespan
Cell Reports, 2020 Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis +6 more
doaj
BMC Research Notes, 2021 Objective The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across tissues with
Crystal L. Sigulinsky +2 more
doaj +1 more source
Response of nucleons to external probes in hedgehog models: I. Electromagnetic polarizabilities [PDF]
Phys.Rev.D47:299-312,1993, 1992 Electromagnetic polarizabilities of the nucleon are analyzed in a hedgehog model with quark and meson degrees of freedom.
arxiv +1 more source
RETRACTED: TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway
Thoracic Cancer, 2021 Background Transmembrane protein 107 (TMEM107) is a key regulator of the cilium composition and Hedgehog signaling. Lower TMEM107 gene copies are correlated with poor prognosis in non‐small cell lung carcinoma (NSCLC). However, TMEM107 protein expression,
Huihui Xu +5 more
doaj +1 more source
Response of nucleons to external probes in hedgehog models: II. General formalism [PDF]
Phys.Rev. D47 (1993) 313-324, 1992 Linear response theory for SU(2) hedgehog soliton models is developed.
arxiv +1 more source
Hedgehog Signaling Pathway and Lung Cancer [PDF]
Journal of Thoracic Oncology, 2007 Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events resulting in the development of neoplasia. We review the biology of the hedgehog signaling pathway and
Ramaswamy Govindan, Vamsidhar Velcheti
openaire +3 more sources
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source