Results 101 to 110 of about 37,007 (262)

The hedgehog pathway in basal cell carcinoma

, 2020
The hedgehog pathway, consisting partly of patched-1 (PTCH1) and smoothened (SMO), is essential in the development of basal cell carcinomas (BCCs). In 2012 vismodegib, a hedgehog pathway inhibitor, registered for the treatment of advanced BCCs (aBCCs ...
Verkouteren, B. J.A., Mosterd, Klara
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Related CCR Translation from Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

, 2011
Related CCR Translation from Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid ...
Walter C. Darbonne (14983139), Daniel D. Von Hoff (9433342), Jennifer A. Low (14982294), Josina C. Reddy (14982291), Raoul Tibes (771250), Kenn L. Zerivitz (14983142), Julie R. Brahmer (13191642), Patricia M. LoRusso (10535356), Mitesh J. Borad (10052187), Glen J. Weiss (11725288), Christine L. Hann (485555), Ilsung Chang (14983136), Richard A. Graham (14982282), Charles M. Rudin (163578)   +13 more
core   +1 more source

Hedgehog signalling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells

Cell Death and Disease
Although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harbouring KRASG12C, acquired resistance to these therapies eventually occurs in most patients.
Chaeyoung Lee, Jawoon Yi, Jihwan Park, Byungyong Ahn, Young-Wook Won, JiHeung Jeon, Byung Ju Lee, Wha Ja Cho, Jeong Woo Park   +8 more
doaj   +1 more source

Phase 1/1b study of azacitidine and hedgehog pathway inhibitor sonidegib in patients with myeloid neoplasms. [PDF]

Cancer, 2023
Tibes R, Kosiorek HE, Dueck AC, Palmer J, Sproat L, Bogenberger J, Hashmi S, Mesa R, Hogan W, Litzow MR, Al-Kali A.   +10 more
europepmc   +1 more source

Loss, persistence and reversal of phenotypic traits

Biological Reviews, EarlyView.
ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni, Giuseppe Fusco, Filippo Nicolini, Heather Bruce, Andrea Luchetti   +4 more
wiley   +1 more source

Numb is a suppressor of Hedgehog signaling and targets Gli1 for Itch-dependent ubiquitination.

, 2006
The developmental protein Numb is a major determinant of binary cell fates(1-3). It is also required for the differentiation of cerebellar granule cell progenitors (GCPs)(4) at a stage of development responsive to the morphogenic glycoprotein Hedehog(5,6)
FERRETTI, ELISABETTA, MARODER M, SCREPANTI I, GRECO A, AND GULINO A., PO, AGNESE, DI MARCOTULLIO L, GIANNINI G, DE SMAELE, Enrico, ALIMANDI, MAURIZIO   +9 more
core  

Humans are not unique: difficult birth is common in placental mammals

Biological Reviews, EarlyView.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

Profile of vismodegib and its potential in the treatment of advanced basal cell carcinoma

Cancer Management and Research, 2013
Muzafar A Macha,1 Surinder K Batra,1,2 Apar Kishor Ganti3,41Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, 2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical ...
Macha MA, Batra SK, Ganti AK
doaj  

Activated hedgehog gene pattern correlates with dismal clinical outcome and tumor microenvironment heterogeneity in hepatocellular carcinoma

Heliyon
Background: Activation of the Hedgehog signaling pathway is linked to the initiation and development of human hepatocellular carcinoma (HCC). However, its impact on clinical outcomes and the HCC microenvironment remains unclear.
Limin Zhen, Yi Zhu, Zhen Wu, Jinyao Liao, Liaoyuan Deng, Qianqian Ma, Qili Wu, Gang Ning, Qiuxiong Lin, Liya Zhou, Yanjie Huang, Zewei Zhuo, Ren Chen, Dongnan Yu   +13 more
doaj   +1 more source