Results 91 to 100 of about 37,007 (262)
Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors
ChemistryOpenEpigenetic targeting of the Hedgehog (HH) signaling pathway has emerged as a possible strategy to combat HH pathway‐driven cancers. In this study, we report on benzo[cd]indol‐2(1H)‐ones as downstream Hedgehog pathway inhibitors.
Dr. Ioannis A. Tsakoumagkos +8 more
doaj +1 more source
Cancer Stem Cell-Targeted Therapy: Harapan Baru Terapi Kanker
Indonesian Journal of Cancer, 2015 Cancer stem cell (CSC) is subpopulation of tumor cell that posses stem cell properties such as self-renewal capacity and able to produce heterogenous progeny.
I GUSTI AYU ARTINI
doaj +1 more source
Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis
Arthritis &Rheumatology, EarlyView.Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo +7 more
wiley +1 more source
Dermatology and Therapy, 2019 Introduction Non-melanoma skin cancer (NMSC) is the most common type of human tumor, with an estimated five million new cases each year. NMSC has been described as having a major impact on the health-related quality of life of the patient.
Alessia Villani +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer
, 2015 Activity in the Hedgehog pathway, which regulates GLI-mediated transcription, is important in organogenesis and stem cell regulation in self-renewing organs, but is pathologically elevated in many human malignancies.
Daniel Suzman, Emmanuel Antonarakis
core +1 more source
Frontiers in Immunology, 2017 Liver fibrosis is a wound healing response initiated by inflammation responding for different iterative parenchymal damages caused by diverse etiologies.
Xin Shen, Yu Peng, Hanmin Li
doaj +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
BMEMat, EarlyView.This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu +9 more
wiley +1 more source
, 2015 Leslie A Fecher,1,3 William H Sharfman2 1Department of Internal Medicine and Dermatology, Indiana University Health Simon Cancer Center, Indianapolis, IN, USA; 2The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA ...
Sharfman WH, Fecher LA
core