Results 71 to 80 of about 1,862,222 (185)
Expression of hedgehog signalling pathway in anaplastic thyroid cancer [PDF]
, 2020 The purpose of this work is to study the activation of the hedgehog signalling pathway is associated with tumour progression in various types of cancer, hence the development of specific antagonists raises hope for new therapeutic strategies.
Annette Wunderlich +9 more
core
Food Chemistry International, EarlyView.Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique +3 more
wiley +1 more source
The PROTAC selectively degrading Bcl-xL represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth. [PDF]
Theranostics, 2022 Zhang S +9 more
europepmc +1 more source
Examining the developmental toxicity of piperonyl butoxide as a Sonic hedgehog pathway inhibitor. [PDF]
Chemosphere, 2021 Rivera-González KS +2 more
europepmc +1 more source
Targeting the Hedgehog Pathway in Cancer: Can the Spines Be Smoothened?
, 2011 Aberrant Hedgehog (Hh) pathway signaling has been suggested to play a role in the development of multiple solid tumors and hematologic malignancies. GDC-0449 is a novel first-in-human, first-in-class smoothened (SMO) inhibitor, which has completed its ...
Lillian L. Siu, Laurie Ailles
core +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
iNew Medicine, EarlyView.This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley +1 more source
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.A whole‐body regenerative annelid was treated with a GSK3 inhibitor. While posterior regeneration was mostly normal, GSK3 inhibition prevented differentiation of anterior‐specific structures and instead produced a persistent, oversized, hyper‐proliferative blastema. This suggests that GSK3 promotes anterior identity and halts proliferation during axial
James D. Nowotny +5 more
wiley +1 more source
Prevention of Early Onset of Breast Cancer With Ashwagandha
Molecular Carcinogenesis, EarlyView.ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm +2 more
wiley +1 more source
The hedgehog pathway in basal cell carcinoma
, 2020 The hedgehog pathway, consisting partly of patched-1 (PTCH1) and smoothened (SMO), is essential in the development of basal cell carcinomas (BCCs). In 2012 vismodegib, a hedgehog pathway inhibitor, registered for the treatment of advanced BCCs (aBCCs ...
Verkouteren, B. J.A., Mosterd, Klara
core +1 more source