Results 61 to 70 of about 1,862,222 (185)

Related CCR Translation from Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding

, 2011
Related CCR Translation from Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein ...
Bert L. Lum (1891498), Daniel D. Von Hoff (9433342), Jin Yan Jin (14982285), Jennifer A. Low (14982294), Josina C. Reddy (14982291), Patricia M. LoRusso (10535356), Richard A. Graham (14982282), Sravanthi Cheeti (2084518), Karin Jorga (14982288), Charles M. Rudin (163578)   +9 more
core   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Qualitative Patient Interviews to Characterize the Human Burden of Advanced Basal Cell Carcinoma Following Hedgehog Pathway Inhibitor Treatment. [PDF]

Dermatol Ther (Heidelb), 2023
Konidaris G, Rofail D, Randall J, LaFontaine PR, Chen CI, Bury D, Geiger A, Sasane M, Symonds T.   +8 more
europepmc   +1 more source

Methylation of Hedgehog pathway genes.

, 2016
Methylation of Hedgehog pathway genes.
Hakon Hakonarson (102913), Steven F. EauClaire (2580163), Shuang Cui (2428774), Zenobia C. Cofer (2580166), Kathleen M. Loomes (503810), John W. Tobias (261377), Randolph P. Matthews (463285), Cecilia Kim (102878)   +7 more
core   +1 more source

The Organocatalytic Approach to Enantiopure 2H- and 3H- Pyrroles: Inhibitors of the Hedgehog Signaling Pathway [PDF]

, 2016
A divergent approach to enantioenriched 2H- and 3H-pyrroles catalyzed by a spirocyclic phosphoric acid is reported that makes use of a Fischer-type indolization and a [1,5]-alkyl shift.
Waldmann, H., List, B., Kötzner, L., Sievers, S., Zheng, Y., Thiel, W., Leutzsch, M., Patil, S.   +7 more
core   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

ABTC-0904: targeting glioma stem cells in GBM: a phase 0/II study of hedgehog pathway inhibitor GDC-0449. [PDF]

J Neurooncol, 2023
Sloan AE, Nock CJ, Ye X, Buerki R, Chang S, Lesser G, Norden A, Cloughesy T, Olson J, Kerstetter-Fogle A, Rich J, Fisher J, Desideri S, Takebe N, Timmer W, Grossman S, Prados M.   +16 more
europepmc   +1 more source

Ni(II), Pd(II), and Pt(II) Complexes of the Hedgehog Pathway Inhibitor GANT61‑D

, 2019
GANT61-D is an important hedgehog pathway inhibitor and an interesting ligand candidate for metal coordination. The first examples of metal complexes of the potent hedgehog pathway inhibitor GANT61-D are described.
Brendan Twamley (1267278), Aisling L. Ryan (7870550), Darren M. Griffith (5729414), András Ozsváth (7870556), Marie-Claire Fitzgerald (7870553), Péter Buglyó (6112334), Brona M. Murphy (7870559)   +6 more
core   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer

, 2015
Activity in the Hedgehog pathway, which regulates GLI-mediated transcription, is important in organogenesis and stem cell regulation in self-renewing organs, but is pathologically elevated in many human malignancies.
Daniel Suzman, Emmanuel Antonarakis
core   +1 more source