Results 41 to 50 of about 37,007 (262)

4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma

Brain Sciences, 2017
This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma.
Shanta M. Messerli, Mariah M. Hoffman, Etienne Z. Gnimpieba, Hella Kohlhof, Ratan D. Bhardwaj   +4 more
doaj   +1 more source

Molecular targeting of prostate cancer cells by a triple drug combination down-regulates integrin driven adhesion processes, delays cell cycle progression and interferes with the cdk-cyclin axis [PDF]

, 2011
Background: Single drug use has not achieved satisfactory results in the treatment of prostate cancer, despite application of increasingly widespread targeted therapeutics.
Eva Juengel, Hudak, Lukasz, Waaga, Ana Maria da Silva Rosa, Roman A Blaheta, Lukasz Hudak, Blaheta, Roman A., Igor Tsaur, Makarević, Jasmina, Haferkamp, Axel, Jens-Michael Seibel, Wedel, Steffen, Haferkamp Axel, Waaga-Gasser Ana, Seibel Jens-Michael, Juengel Eva, Blaheta Roman A, Makarević Jasmina, Waaga-Gasser, Ana, Jasmina Makarević, Axel Haferkamp, Wedel Steffen, Jüngel, Eva, Seibel, Jens-Michael, Ana Waaga-Gasser, Tsaur Igor, Juengel, Eva, Wedel, Steffen Alexander, Tsaur, Igor, Hudak Lukasz, Steffen Wedel   +29 more
core   +1 more source

Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma [PDF]

Clinical Cancer Research, 2018
Abstract Purpose: The role of cholesterol biosynthesis in hedgehog pathway activity and progression of hedgehog pathway medulloblastoma (Hh-MB) were examined in vivo. Statins, commonly used cholesterol-lowering agents, were utilized to validate cholesterol biosynthesis as a therapeutic target for Hh-MB.
Renata E, Gordon, Li, Zhang, Suraj, Peri, Yin-Ming, Kuo, Fang, Du, Brian L, Egleston, Jessica M Y, Ng, Andrew J, Andrews, Igor, Astsaturov, Tom, Curran, Zeng-Jie, Yang   +10 more
openaire   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers

, 2010
Background: The hedgehog signaling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are being developed for potential use in cancer. Objectives/Methods: The objective of this evaluation
Doggrell, Sheila Anne
core   +1 more source

NOVEL APPROACH TO THE HEDGEHOG SIGNALING PATHWAY: COMBINED TREATMENT OF SMO AND PTCH INHIBITORS

, 2023
Purpose: Abnormal Sonic Hedgehog signaling Pathway (Shh) activation is crucial for the development of cancer stem cells, neoplastic growth, and epithelial-mesenchymal transition processes in adulthood.
Yasemin BAŞBINAR, Karadag, Aslihan, Başbınar, Yasemin, Aslıhan KARADAĞ   +3 more
core   +1 more source

The Proteasome and Cul3-Dependent Protein Ubiquitination Is Required for Gli Protein-Mediated Activation of Gene Expression in the Hedgehog Pathway

Cells
Many cellular processes are regulated by proteasome-mediated protein degradation, including regulation of signaling pathways and gene expression. Among the pathways regulated by the ubiquitin–proteasome system is the Hedgehog pathway and its downstream ...
Tomasz Uśpieński, Paweł Niewiadomski
doaj   +1 more source

Sox11 is required to maintain proper levels of Hedgehog signaling during vertebrate ocular morphogenesis. [PDF]

PLoS Genetics, 2014
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts.
Lakshmi Pillai-Kastoori, Wen Wen, Stephen G Wilson, Erin Strachan, Adriana Lo-Castro, Marco Fichera, Sebastiano A Musumeci, Ordan J Lehmann, Ann C Morris   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer

Frontiers in Pharmacology, 2018
HIGHLIGHTSPreliminary results of this work were presented at the 2016 Academic Surgical Congress, Jacksonville (FL), February 2–4 2016 (Original title: Selective Smo-Inhibition Interferes With Cellular Energetic Metabolism In Colorectal Cancer)This study
Paolo Magistri, Cecilia Battistelli, Raffaele Strippoli, Niccolò Petrucciani, Teijo Pellinen, Lucia Rossi, Livia Mangogna, Paolo Aurello, Francesco D'Angelo, Marco Tripodi, Giovanni Ramacciato, Giuseppe Nigri   +11 more
doaj   +1 more source