Results 21 to 30 of about 37,007 (262)

Hedgehog pathway inhibitors – current status and future prospects [PDF]

Infectious Agents and Cancer, 2012
تتكون بروتينات القنفذ (HH) من مجموعة من البروتينات المفرزة التي تنظم نمو الخلايا وتمايزها وبقائها. وقد تورط التنشيط غير المناسب لمسار إشارات HH في تطور مجموعة متنوعة من السرطانات. مثبطات مسار القنفذ هي فئة جديدة نسبيًا من العوامل العلاجية التي تعمل من خلال استهداف البروتينات المشاركة في تنظيم مسار HH (PTCH و SMO و Gli). تعمل معًا كآفاق جديدة ومثيرة، مع
A Sheikh, Arsalan Ahmad Alvi, Hafiz Muhammad Aslam, Abdul Haseeb   +3 more
openaire   +3 more sources

RETRACTED: TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway

Thoracic Cancer, 2021
Background Transmembrane protein 107 (TMEM107) is a key regulator of the cilium composition and Hedgehog signaling. Lower TMEM107 gene copies are correlated with poor prognosis in non‐small cell lung carcinoma (NSCLC). However, TMEM107 protein expression,
Huihui Xu, Song Dun, Ying Gao, Jian Ming, Linping Hui, Xueshan Qiu   +5 more
doaj   +1 more source

Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors [PDF]

Chemistry – A European Journal, 2021
AbstractWithanolides constitute a well‐known family of plant‐based alkaloids characterised by widespread biological properties, including the ability of interfering with Hedgehog (Hh) signalling pathway. Following our interest in natural products and in anticancer compounds, we report here the synthesis of a new class of Hh signalling pathway ...
Bonandi E., Mori M., Infante P., Basili I., Di Marcotullio L., Calcaterra A., Catti F., Botta B., Passarella D.   +8 more
openaire   +3 more sources

Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids

Frontiers in Pharmacology, 2022
Although Cisplatin (DDP) is a widely used first-line chemotherapy medication, DDP resistance is one of the main causes of treatment failure in advanced lung cancer.
Yi Han, Jianquan Shi, Ziwei Xu, Yushan Zhang, Xiaoqing Cao, Jianhua Yu, Jie Li, Shaofa Xu   +7 more
doaj   +1 more source

Spontaneous resolution of advanced basal cell carcinoma after short-pulse treatment with hedgehog pathway inhibitor [PDF]

JAAD Case Reports, 2016
Audrey A Jacobsen, John Strasswimmer
exaly   +2 more sources

Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents [PDF]

Journal of Medicinal Chemistry, 2009
Cancer drug discovery has undergone a paradigm change over the past few years, from predominantly cytotoxic agent-based therapy to therapy aimed at genetic and molecular targets, thanks to a growing understanding of the genes and pathways responsible for cancer initiation and progression and to new drug discovery technologies. The success of drugs like
Neeraj, Mahindroo, Chandanamali, Punchihewa, Naoaki, Fujii   +2 more
openaire   +2 more sources

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

Efficacy of Hedgehog Pathway Inhibitors in Basal Cell Carcinoma [PDF]

Molecular Cancer Therapeutics, 2015
Abstract Basal cell carcinoma (BCC) is the most commonly diagnosed cancer. While most BCCs are amenable to surgery, some tumors can reach a more advanced stage or metastasize, and become ineligible for surgical resection or radiotherapy. Abnormal activation of the Hedgehog (Hh) pathway is a key driver in BCC pathophysiology. Consequently,
Nicole, Basset-Seguin, Hayley J, Sharpe, Frederic J, de Sauvage   +2 more
openaire   +2 more sources

Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. [PDF]

, 2013
Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (Gli1 ...
Hennen, Elisabeth, Olga Bermudez, Oliver Eickelberg, Olga Bermudez (410727), Ina Koch (7903), Oliver Eickelberg (153848), Eickelberg, O., Bermudez, O., Koch, I., Lindner, Michael, Elisabeth Hennen, Hennen, E., Koch, Ina, Elisabeth Hennen (410728), Bermudez, Olga, Michael Lindner, Ina Koch, Michael Lindner (383308), Lindner, M., Eickelberg, Oliver   +19 more
core   +1 more source

Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer [PDF]

Drug Safety, 2019
The hedgehog pathway, for which sonic hedgehog (Shh) is the most prominent ligand, is highly conserved and is tightly associated with embryonic development in a number of species. This pathway is also tightly associated with the development of several types of cancer, including basal cell carcinoma (BCC) and acute promyelocytic leukemia, among many ...
Richard L. Carpenter, Haimanti Ray
openaire   +2 more sources