Results 31 to 40 of about 37,007 (262)

Clinical implications of hedgehog signaling pathway inhibitors

Chinese Journal of Cancer, 2011
Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis.
Liu, Hailan, Gu, Dongsheng, Xie, Jingwu
openaire   +3 more sources

Smoothened as a new therapeutic target for human osteosarcoma

Molecular Cancer, 2010
Background The Hedgehog signaling pathway functions as an organizer in embryonic development. Recent studies have demonstrated constitutive activation of Hedgehog pathway in various types of malignancies.
Nagao Hiroko, Gao Hui, Matsunoshita Yukihiro, Sasaki Hiromi, Setoguchi Takao, Hirotsu Masataka, Kunigou Osamu, Komiya Setsuro   +7 more
doaj   +1 more source

GLI1 confers profound phenotypic changes upon LNCaP prostrate cancer cells that include the acquisition of a hormone independent state [PDF]

, 2011
The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited.
Nadendla Sandeep K., Thomas, GJ, Ward, M, Lucia S. Bianchi, Hazan Allon, Ghali, Lucy, Matt Ward, Ghali Lucy, Lucia S Bianchi, Thomas, Gareth J., Michael P Philpott, Ghali, L, Philpott Michael P., Sandeep K. Nadendla, Ward Matt, Moutasim, K, Neill, GW, David M Prowse, Thomas Gareth J., Prowse, DM, Sandeep K Nadendla, Philpott, MP, Bianchi, Lucia S., Mahmoud Naase, Harper, LJ, Naase Mahmoud, Hazan, Allon, Moutasim Karwan, Philpott, Michael P., Moutasim, Karwan, Lisa J Harper, Nadendla, Sandeep K., Prowse David M., Gareth J. Thomas, Harper Lisa J., Ward, Matt, Lucy Ghali, Nadendla, SK, Allon Hazan, Hazan, A, Bianchi Lucia S., Gareth J Thomas, Graham W Neill, Karwan Moutasim, David M. Prowse, Naase, Mahmoud, Bianchi, LS, Lisa J. Harper, Prowse, David M., Harper, Lisa J., Graham W. Neill, Naase, M, Neill Graham W., Michael P. Philpott, Neill, Graham W.   +54 more
core   +1 more source

Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis. [PDF]

PLoS ONE, 2013
Hedgehog signaling pathway activation has been implicated in the pathogenesis of NASH. Despite this concept, hedgehog pathway inhibitors have not been explored. Thus, we examined the effect of vismodegib, a hedgehog signaling pathway inhibitor, in a diet-
Petra Hirsova, Samar H Ibrahim, Steven F Bronk, Hideo Yagita, Gregory J Gores   +4 more
doaj   +1 more source

Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma

Cells, 2022
Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population.
Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin   +13 more
doaj   +1 more source

Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis

, 2012
BackgroundOsteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of osteophytes.ObjectiveTo examine the hypothesis that inhibition of ...
Ruiz-Heiland, Gisela, Stock, M, Pawel Zerr, Schett, Georg, Baum, W, Wolfgang Baum, Michael Stock, Horn, Angelika, Hofstetter, W, Ruiz-Heiland, G, Georg Schett, Distler, Jörg H, Hofstetter, Willy, Zwerina, J, Zwerina, Jochen, Horn, A, Gisela Ruiz-Heiland, Jörg H Distler, Zerr, Pawel, Willy Hofstetter, Jochen Zwerina, Angelika Horn, Zerr, P, Baum, Wolfgang, Nimmerjahn, F, Stock, Michael, Schett, G, Falk Nimmerjahn, Nimmerjahn, Falk, Distler, JH   +29 more
core   +2 more sources

The role of the Bmi1-GSK3β pathway in glioblastoma [PDF]

, 2010
Malignant gliomas remain one of the deadliest of all cancers despite maximal therapy. They present unique challenges to therapy with a median survival of 12 months.
Korur, Serdar
core   +1 more source

Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling

Cancer Cell International, 2008
Background Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation.
Prowse David M, Shaw Greg
doaj   +1 more source

The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma via the Noncanonical Hedgehog Signaling Pathway

Frontiers in Pharmacology, 2021
Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system. Temozolomide (TMZ)–based adjuvant treatment has improved overall survival, but clinical outcomes remain poor; TMZ resistance is one of the main reasons for ...
Ming Ji, Ming Ji, Zhihui Zhang, Songwen Lin, Chunyang Wang, Jing Jin, Jing Jin, Nina Xue, Heng Xu, Xiaoguang Chen, Xiaoguang Chen   +10 more
doaj   +1 more source

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Nature Communications, 2019
Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to the
Jennifer Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon   +22 more
doaj   +1 more source