Results 11 to 20 of about 37,007 (262)
Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma [PDF]
Oncologist, 2016 International audienceAbnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell carcinoma (BCC). Vismodegib, a first-in-class small-molecule inhibitor of hedgehog pathway signaling, is approved by regulatory ...
Mario E Lacouture +2 more
exaly +4 more sources
Activation of the hedgehog pathway in chronic myelogeneous leukemia patients [PDF]
Journal of Experimental & Clinical Cancer Research, 2011 Background Hedgehog (Hh) signaling pathway is involved in regulation of many tissues development and oncogenesis. Recently, Hh signaling has been identified as a required functional pathway for leukemia stem cells(LSCs), and loss of this pathway impairs ...
Long Bing +4 more
doaj +2 more sources
Cell Death and Disease, 2017 mTORC2 is aberrantly activated in cancer and therefore is considered to be an important therapeutic target. The hedgehog pathway, which is also often hyperactivated, regulates transcription of several genes associated with angiogenesis, metastasis ...
Samarpan Maiti +3 more
doaj +2 more sources
Hedgehog Pathway Blockade Inhibits Melanoma Cell Growth in Vitro and in Vivo
Pharmaceuticals, 2013 Previous reports have demonstrated a role for hedgehog signaling in melanoma progression, prompting us to explore the therapeutic benefit of targeting this pathway in melanoma.
Eva Hernando +10 more
doaj +2 more sources
Scientific ReportsThe Hedgehog signaling pathway plays a crucial role in folliculogenesis; however, the association between FF-MAS oxysterol activity in folliculogenesis and the Hedgehog signaling pathway has not been revealed.
Selim Zırh +5 more
doaj +3 more sources
A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth. [PDF]
Cancers (Basel), 2019 Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Lospinoso Severini L +14 more
europepmc +4 more sources
Endocannabinoids are conserved inhibitors of the Hedgehog pathway [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Hedgehog proteins regulate development and tissue homeostasis. They signal through activation of the transmembrane protein Smoothened. Smoothened hyperactivation underlies development of many tumors. Smoothened activity can be modulated by several synthetic small molecules, which have shown promise in the clinic.
Khaliullina, H. +4 more
openaire +3 more sources
Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. [PDF]
PLoS ONE, 2011 TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor pathway, to promote cytotoxicity.
Satoshi Kurita +8 more
doaj +1 more source
Combined cemiplimab and radiotherapy for advanced basal cell carcinoma: A case report
SAGE Open Medical Case Reports, 2023 Advanced basal cell carcinoma may be treated with systemic therapies such as hedgehog pathway inhibitors or programmed cell death protein 1 inhibitors, namely cemiplimab.
Sidra Sarfaraz +2 more
doaj +1 more source
Design of Hedgehog pathway inhibitors for cancer treatment [PDF]
Medicinal Research Reviews, 2018 AbstractHedgehog (Hh) signaling is involved in the initiation and progression of various cancers and is essential for embryonic and postnatal development. This pathway remains in the quiescent state in adult tissues but gets activated upon inflammation and injuries.
Jitender Bariwal +3 more
openaire +2 more sources