Results 11 to 20 of about 1,862,222 (185)

Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1 [PDF]

Nat Commun, 2023
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease –
Bagka, Meropi, Heritier, Margaux, Sascha Hoogendoorn, Hoogendoorn, Sascha, Schwaemmle, Hanna, Braun, Simon, Meropi Bagka, Margaux Héritier, Hyeonyi Choi, Simon M. G. Braun, Leonardo Scapozza, Hanna Schwaemmle, Yibo Wu, Wu, Yibo, Quentin T. L. Pasquer, Choi, Hyeonyi, Pasquer, Quentin Titouan Loïc, Scapozza, Leonardo   +17 more
core   +2 more sources

Update on Hedgehog Pathway Inhibitor Therapy for Patients with Basal Cell Naevus Syndrome or High-frequency Basal Cell Carcinoma [PDF]

Acta Derm Venereol, 2022
Some patients with basal cell carcinoma develop a large number of basal cell carcinomas during their lives. The most common underlying genetic disease that causes multiple basal cell carcinomas is basal cell naevus syndrome. Basal cell naevus syndrome is
Reinders, Marie G H C, Sinx, Kelly A E, VERKOUTEREN, Babette J. A., REINDERS, Marie G. H. C., AARTS, Maureen J. B., Mosterd, Klara, SINX, Kelly A. E., Verkouteren, Babette J A, Aarts, Maureen J B, Babette J.A. Verkouteren, Marie G.H.C. Reinders, Maureen J.B. Aarts, Klara Mosterd, Kelly A.E. Sinx   +13 more
core   +2 more sources

Characterization andManagement of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced BasalCell Carcinoma [PDF]

Oncologist, 2016
International audienceAbnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell carcinoma (BCC). Vismodegib, a first-in-class small-molecule inhibitor of hedgehog pathway signaling, is approved by regulatory ...
Paolo Antonio Ascierto, Axel Hauschild, Neves, Rogerio, I., Neves, Rogerio,, Mario E. Lacouture, Rainer Kunstfeld, Puig, Susana, Sokolof, Jonas, Fife, Kate, Kate Fife, R. Kunstfeld, Neves, Rogerio I, Susana Puig, A. Sekulic, L. Licitra, Peris, Ketty, Dummer, Reinhard, M. E. Lacouture, Nicole Basset-Seguin, Kunstfeld, Rainer, Brigitte Dréno, J. Sokolof, Lacouture, Mario,, R. I. Neves, A. Hauschild, S. Ernst, K. Peris, Aleksandar Sekulic, S. Puig, K. Fife, Licitra, Lisa, Dréno, Brigitte, Lisa Licitra, Ketty Peris, Basset-Seguin, N., Lacouture, Mario E, Ernst, Scott, R. Dummer, Basset-Seguin, Nicole, Rogerio I. Neves, Jonas Sokolof, Ascierto, Paolo Antonio, Hauschild, Axel, Reinhard Dummer, Sekulic, Aleksandar, N. Basset Seguin, P. A. Ascierto, Scott Ernst, Lacouture, Mario, E., B. Dréno, Dummer R, Peris K, Ascierto PA, Dréno B, Lacouture ME, Sekulic A, Ernst S, Sokolof J, Puig S, Licitra L, Neves RI, Fife K, Hauschild A, Ascierto P, Kunstfeld R, Basset-Seguin N   +65 more
core   +2 more sources

The role of Sulf1 during Sonic hedgehog mediated neural patterning [PDF]

, 2011
Heparan sulphate proteoglycans (HSPGs) are large molecules distributed ubiquitously, both at the cell surface and within the extracellular matrix. These molecules are known to play essential roles in developmental cell signalling, and the differential ...
Ramsbottom, Simon.A
core   +5 more sources

Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems [PDF]

, 2007
PhDEmbryonic development is regulated by a number of signalling pathways, Which are critical for normal growth. Many of these genes then continue to play an important role in the regulation of cell growth and differentiation in adult.
Ikram, Mohammed S, Ikram, Mohammed. S.
core   +3 more sources

The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers [PDF]

, 2010
Background: The hedgehog signaling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are being developed for potential use in cancer. Objectives/Methods: The objective of this evaluation
Doggrell, Sheila Anne, Sheila A Doggrell
core   +1 more source

Activation of the hedgehog pathway in chronic myelogeneous leukemia patients [PDF]

, 2011
Background Hedgehog (Hh) signaling pathway is involved in regulation of many tissues development and oncogenesis. Recently, Hh signaling has been identified as a required functional pathway for leukemia stem cells(LSCs), and loss of this pathway impairs ...
Long Bing, Huanling Zhu, Zhu Cuixia, Zhu Huanling, Meng Wentong, Ting Liu, Wentong Meng, Cuixia Zhu, Bing Long, Liu Ting   +9 more
core   +1 more source

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation [PDF]

, 2009
We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V, Ross, Susan E, Rowbotham, Nicola J, Crompton, T, Hager-Theodorides, Ariadne L, Shah, DK, Shah, Divya K, Drakopoulou, Ekati, Lanske, Beate, Crompton, Tessa, Dessens, Johannes T, Drakopoulou, E, Rowbotham, NJ, Dessens, JT, Ross, SE, Lanske, B, Outram, SV, Hager-Theodorides, AL   +17 more
core   +1 more source

NOVEL APPROACH TO THE HEDGEHOG SIGNALING PATHWAY: COMBINED TREATMENT OF SMO AND PTCH INHIBITORS

, 2023
Purpose: Abnormal Sonic Hedgehog signaling Pathway (Shh) activation is crucial for the development of cancer stem cells, neoplastic growth, and epithelial-mesenchymal transition processes in adulthood.
Yasemin BAŞBINAR, Karadag, Aslihan, Başbınar, Yasemin, Aslıhan KARADAĞ   +3 more
core   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source